Multicenter Network of Neonatal Intensive Care Units

新生儿重症监护室多中心网络

• 批准号: 6891934
• 负责人: JON E. TYSON
• 金额: $ 73.49万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6891934
• 关键词: clinical research; clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

The PI is Jon Tyson, MD, MPH, is the Michelle Bain Distinguished Professor of Medicine and Public Health, Director of the Center for Population Health and Evidence-Based Medicine, and a Professor of Pediatrics, Obstetrics, and Epidemiology at UT Houston. Th Co-PI is Kathleen Kennedy, MD who is an Associate Professor of Pediatrics and the Director of the Perinatal Epidemiology Program UT Houston was added to the Network in 1998 when the PI and Co-PI moved from UT Southwestern. UT Houston provides: A. A large and growing patient population. A total of 9,000 total births and 350 VLBW infants are projected this year for our 2 teaching hospitals: Memorial Hermann Hospital (a private hospital with an expanding referral base including 9 hospitals in the Memorial Hermann system [3 staffed by our Ob. Faculty]) and Lyndon Baines Johnson Hospital (a large county hospital with an increasing population). UT Houston's enrollment in the Glutamine Trial exceeds that for all but 2 of the other 13 Network centers. B. Strong, and highly supportive leadership at UT Houston. The Dean (Max Buja, MD) recruited Dr. Tyson to promote clinical research. The Ob. Chairman (Larry Gilstrap) is a perinatal investigator and Network consultant. The Pediatrics Chairman (John Sparks, MD) is a neonatologist and Network advocate. The Neonatology Director (Fernando Moya, MD) is Hermann Physician of the Year and skilled in conducting clinical research, eliciting hospital support, and augmenting enthusiasm for Network studies. C. An experienced and highly committed PI and Co-PI. Dr Tyson has been a PI for 13 years; Dr. Kennedy, Co-PI for 9 years and acting PI for 1 year. In the past 4 years, they have been an author on 16 Network publications, 3 as 1st author; 3 as 2nd author, and 1 as 3rd author. (4 of these were published in New England Journal or JAMA.) In moving to Houston, Dr. Tyson petitioned NICHD to include both UT Southwestern and UT Houston (rather than UT Houston only) in the Network and has served as PI for both. He has helped the Co-PI at UT Southwestern to apply as PI there for the next funding cycle. Dr. Tyson has involved multiple other faculty and fellows in the Network including Robert Lasky, PhD a developmental psychologist with expertise in neural processing; Terri Major-Kincade, MD,MPH, 1st recipient of the Network Specialized Clinical Investigator Development Award; and Martin Blakely, MD a pediatric surgeon whose K23 proposal (Dr. Tyson as mentor) is focused on Network studies. D. Methodological and multidisciplinary expertise. The Network can further advance the methods of clinical research and enrich the evaluation of important neonatal issues. Dr. Tyson is an epidemiologist and neonatologist, the PI for the NIH-funded Clinical Research Curriculum, and Director of the Master's Degree Program in Clinical Research to start here. The Center for Population Health and Evidence- Based Medicine that he directs includes 9 faculty with expertise in clinical or population-based epidemiology, biostatistics, developmental psychology, health care economics, and/or bioethics; 3 of these faculty are now involved in Network studies. John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001.

该 PI 是乔恩·泰森 (Jon Tyson)，医学博士、公共卫生硕士，是米歇尔·贝恩医学和公共卫生杰出教授、人口健康和循证医学中心主任，以及 UT 休斯顿儿科、产科和流行病学教授。联合 PI 是凯瑟琳·肯尼迪 (Kathleen Kennedy) 医学博士，她是儿科副教授兼围产期流行病学项目主任 UT 休斯顿分校于 1998 年加入该网络，当时 PI 和联合 PI 从 UT 西南大学调来。 UT 休斯敦大学提供： A. 大量且不断增长的患者群体。今年，我们的 2 家教学医院预计将迎来 9,000 名新生儿和 350 名极低出生体重婴儿： 赫尔曼纪念医院（一家私立医院，转诊基础不断扩大，包括纪念赫尔曼系统中的 9 家医院 [3 家由我们的产科教员组成]）和林登贝恩斯约翰逊医院（人口不断增加的大型县医院）。 UT 休斯顿参加谷氨酰胺试验的人数超过了其他 13 个网络中心中除 2 个之外的所有中心。 B. UT 休斯敦大学强大且高度支持的领导层。院长（Max Buja，医学博士）聘请泰森博士来促进临床研究。奥布。主席（拉里·吉尔斯特拉普）是一名围产期调查员和网络顾问。儿科主席（John Sparks，医学博士）是一位新生儿科医生和网络倡导者。新生儿科主任（医学博士 Fernando Moya）是赫尔曼年度医师，擅长开展临床研究、获得医院支持以及激发网络研究的热情。 C. 经验丰富且高度忠诚的 PI 和 Co-PI。 Tyson 博士担任 PI 已有 13 年； Kennedy 博士，担任联合 PI 9 年，代理 PI 1 年。近4年来，以作者身份发表网络出版物16篇，其中第一作者3篇；第二作者 3 人，第三作者 1 人。 （其中 4 篇发表在《新英格兰杂志》或《美国医学会杂志》上。）在搬到休斯顿时，泰森博士请求 NICHD 将 UT 西南大学和 UT 休斯顿大学（而不是仅 UT 休斯顿大学）纳入网络，并担任两者的 PI。他帮助 UT Southwestern 的 Co-PI 申请成为下一个资助周期的 PI。泰森博士还参与了该网络中的多名其他教职人员和研究员，其中包括罗伯特·拉斯基博士，一位在神经处理方面具有专业知识的发展心理学家； Terri Major-Kincade，医学博士、公共卫生硕士，第一届网络专业临床研究者发展奖获得者； Martin Blakely 医学博士是一位小儿外科医生，他的 K23 提案（泰森博士作为导师）专注于网络研究。 D. 方法论和多学科专业知识。该网络可以进一步推进临床研究方法并丰富对重要新生儿问题的评估。 Tyson 博士是一位流行病学家和新生儿学家、NIH 资助的临床研究课程的 PI 以及临床研究硕士学位项目的主任。他领导的人口健康和循证医学中心包括 9 名在临床或人群流行病学、生物统计学、发展心理学、医疗保健经济学和/或生物伦理学方面具有专业知识的教师；其中 3 名教师现在参与网络研究。 John C. Sinclair 医学博士是一位著名的新生儿学家、临床流行病学家和网络顾问，将于 2001 年 1 月加入该中心。