SUPPORT SERVICES FOR THE PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS IMPLEMENTATION SCIENCE NETWORK

通过全面护理连续体为资源有限环境中受艾滋病毒影响的青少年提供预防和治疗支持服务 实施科学网络

• 批准号: 10917617
• 负责人: BARBARA DRIVER
• 金额: $ 146.15万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-25 至 2024-08-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10917617
• 关键词: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Affect; Africa South of the Sahara; Age; Asia; Award; Brazil; Caring; Childhood; Clinical Protocols; Clinical Research; Clinical Trials; Collection; Communicable Diseases; Communication; Communities; Comprehensive Health Care; Continuity of Patient Care; Contracts; Country; Development; Education; Effectiveness; Ensure; Equipment; Family; Funding; Geography; Goals; Grant; HIV; HIV Infections; Health; Health system; Human Resources; Incidence; Income; Individual; Information Systems; Infrastructure; Intervention; Laws; Leadership; Mission; Monitor; National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; Outcome; Policies; Population; Prevention; Public Health; Public Health Practice; Publications; Qualifying; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resource-limited setting; Risk; Services; Statistical Models; Structure; Study models; Surveys; Translating; Translations; U-Series Cooperative Agreements; United States National Institutes of Health; Viral; Work; Youth; behavioral and social science; clinical development; clinical research site; data infrastructure; data management; education research; effectiveness/implementation study; implementation science; improved; innovation; multidisciplinary; performance site; prevention service; programs; public health intervention; research clinical testing; social science research; success; web site; working group

Support Services for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN) (UG1/UM2) Program The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support for logistical and operational coordination, website and communication management, analytic and data management, infrastructure for emerging research, regulatory, and monitoring of research activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN) (UG1/UM2) Program. The NICHD and partner NIH Institutes anticipate funding 8 PATC3H-IN UG1 awards in Asia and throughout sub-Saharan Africa in 2023 through a cooperative agreement mechanism for interventions of high public health significance: The prevention of new HIV infections among adolescents at risk, and the identification of, linkage to and retention in care of, and long-term viral suppression among youth living with HIV in low-to-middle income countries with high HIV burden. The PATC3H-IN network will expand and/or improve on successes achieved by its predecessor, PATC3H, to new geographic settings and/or risk populations and stimulate much needed implementation science (IS) research in the prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). PATC3H-IN will establish a network of investigators with multidisciplinary expertise on the youth-specific PHCC and in IS research, whose mission will be to evaluate promising prevention innovations contextually and developmentally tailored for HIV uninfected at-risk youth, and treatment and care interventions for youth living with HIV which have demonstrated efficacy and/or effectiveness in adolescent or adult populations and to translate them into public health practices. The structure of PATC3H-IN will consist of multiple interdependent functional components: (1) Five Clinical Research Centers (CRC) awarded through the UG1 grant mechanism; (2) one Implementation Science Coordinating Center (ISCC) to be awarded through a UM2 grant mechanism in 2024; and (3) a Scientific Leadership Committee (SLC). The CRCs will conduct clinical research and clinical trials, including implementation, effectiveness, and hybrid implementation-effectiveness studies at their 8-or more participating Clinical Research Performance Sites (CRPS). The ISCC will establish infrastructure to support research education and capacity building across PATC3H-IN, as well as infrastructure for stakeholder engagement in and dissemination of findings from PATC3H-IN and advanced statistical modeling support across PATC3H-IN. The ISCC will also provide infrastructure for conducting foundational research to support the work of clinical sites, including possible modeling studies and translation projects, as well as national surveys, and/or systematic collection and analysis of relevant policies and laws. Lastly, the SLC will be responsible for PATC3H-IN governance, oversight, and coordination, and will develop and implement the network research agenda, convening working groups as needed, prioritizing emerging research projects, efficiently managing the development of clinical protocols, implementing and completing clinical trials, and ensuring timely publication and communication of results.

通过综合护理提供预防和治疗支持服务 资源有限环境中受艾滋病毒影响的青少年的连续体实施科学 网络 (PATC3H-IN) (UG1/UM2) 程序 尤尼斯·肯尼迪·施赖弗国家儿童健康和人类发展研究所 (NICHD) 需要为后勤和运营协调、网站和通信管理、分析和数据管理、新兴研究基础设施、预防和治疗研究活动的监管和监测提供支持通过资源有限环境中受艾滋病毒影响的青少年的综合护理连续体实施科学网络 (PATC3H-IN) (UG1/UM2) 计划。 NICHD 和合作伙伴 NIH 研究所预计将于 2023 年通过合作协议机制为亚洲和整个撒哈拉以南非洲地区的 8 个 PATC3H-IN UG1 奖项提供资助，用于具有高度公共卫生意义的干预措施：预防高危青少年中新发艾滋病毒感染，以及在艾滋病毒负担较高的中低收入国家中，对感染艾滋病毒的青年进行识别、联系和保留护理，并对其进行长期病毒抑制。 PATC3H-IN 网络将扩展和/或改进其前身 PATC3H 所取得的成功，以适应新的地理环境和/或高危人群，并促进在高危青少年中预防新的艾滋病毒感染方面急需的实施科学 (IS) 研究识别、联系和保留中低收入国家（LMIC）感染艾滋病毒的青年的护理和长期病毒抑制。 PATC3H-IN 将建立一个由具有针对青少年的 PHCC 和 IS 研究的多学科专业知识的研究人员网络，其任务是评估针对未感染 HIV 的高危青少年的有前景的预防创新，以及针对未感染 HIV 的高危青少年的治疗和护理干预措施。已在青少年或成人群体中证明功效和/或有效性，并将其转化为公共卫生实践。 PATC3H-IN的结构将由多个相互依赖的功能组件组成：（1）通过UG1资助机制授予的五个临床研究中心（CRC）； (2) 2024年将通过UM2资助机制授予一个实施科学协调中心（ISCC）； (3) 科学领导委员会 (SLC)。 CRC 将在其 8 个或更多参与的临床研究绩效中心 (CRPS) 开展临床研究和临床试验，包括实施、有效性以及混合实施-有效性研究。 ISCC 将建立基础设施来支持整个 PATC3H-IN 的研究教育和能力建设，以及用于利益相关者参与和传播 PATC3H-IN 发现的基础设施以及跨 PATC3H-IN 的高级统计模型支持。 ISCC 还将提供进行基础研究的基础设施，以支持临床中心的工作，包括可能的建模研究和翻译项目，以及国家调查和/或相关政策和法律的系统收集和分析。最后，SLC 将负责 PATC3H-IN 的治理、监督和协调，并将制定和实施网络研究议程，根据需要召集工作组，优先考虑新兴研究项目，有效管理临床方案的制定，实施和完成临床试验，并确保及时公布和传达结果。