Multispectral diagnostic imaging of the iris

虹膜多光谱诊断成像

• 批准号: 7156016
• 负责人: ANA S LUKIC
• 金额: $ 38.48万
• 依托单位: PREDICTEK, LLC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156016
• 关键词: clinical research; eye; lighting

DESCRIPTION (provided by applicant): The objective of this project is to develop a prototype of a new diagnostic imaging device for use by eye care practitioners. Specifically, the instrument we envision will detect, quantify, and report information obtained by multispectral imaging of the iris using visible and near-infrared transillumination (i.e., light directed through the skin, then reflected out through the iris from within the eye). Visible-light transillumination, with visual evaluation by the practitioner, is routinely used in clinical practice. However, this approach suffers from low sensitivity, especially when the subject has dark-colored irides and/or when the disease is in its early stages or is otherwise subtle. We propose that multispectral digital imaging, with automated image analysis, will be a major step forward for evaluation of diseases of the iris. The anticipated advantages of this approach lie not only in improved diagnostic performance, but also in the benefits offered by digital imaging, including automated image analysis, archiving and reporting of results, and longitudinal tracking of disease progression. The device is expected to have clinical importance for the following disorders: pigmentary dispersion syndrome and secondary glaucoma, Fuchs' heterochromic iridocyclitis, ocular albinism in infants, and iridociliary cysts. Research in this Phase II SBIR project will focus on technical development of the imaging instrumentation and image processing/analysis approaches required. Duplicates of the prototype developed in this project will be deployed at the clinics of the Illinois Eye Institute, University of Illinois-Chicago, and University of Michigan for collection of patient data needed for training of automated detection methods. If successful, the proposed instrument will permit visualization of eye disease in cases where detection is difficult or impossible by currently available technology. This Phase II SBIR project will focus on development of a prototype device for imaging the iris (pigmented portion at the front of the eye). The device will acquire, store, and automatically analyze images to detect defects in the iris that are associated with glaucoma.

描述（由申请人提供）：该项目的目的是开发一种新的诊断成像设备的原型，以供眼保健从业人员使用。具体而言，我们设想的仪器将使用可见的和近二世的透明仪检测，量化和报告通过对虹膜的多光谱成像获得的信息（即，通过皮肤引导的光，然后从眼睛内部通过虹膜反射出来）。可见光的透明量和从业者的视觉评估通常用于临床实践。但是，这种方法的灵敏度低，尤其是当受试者患有深色虹彩和/或疾病处于早期阶段或其他微妙时。我们建议，具有自动图像分析的多光谱数字成像将是评估虹膜疾病的重要一步。这种方法的预期优势不仅在于提高诊断性能，还在于数字成像所提供的好处，包括自动化图像分析，归档和报告结果以及疾病进展的纵向跟踪。预计该设备对以下疾病具有临床重要性：色素色散综合征和继发性青光眼，Fuchs的异质虹膜虹膜细胞炎，婴儿的眼睛白化病和虹膜囊肿囊肿。在此II阶段SBIR项目中的研究将重点放在成像仪器和图像处理/分析方法的技术开发上。该项目开发的原型的重复项将在伊利诺伊州眼科研究所，伊利诺伊州 - 芝加哥大学和密歇根大学的诊所部署，以收集培训自动检测方法所需的患者数据。如果成功，则建议的仪器将在当前可用的技术难以检测或不可能的情况下可视化眼病。该II期SBIR项目将着重于开发用于成像虹膜的原型设备（眼前的色素部分）。该设备将获取，存储和自动分析图像以检测与青光眼相关的虹膜中的缺陷。