Multispectral diagnostic imaging of the iris

虹膜多光谱诊断成像

• 批准号: 6791776
• 负责人: ANA S LUKIC
• 金额: $ 10万
• 依托单位: PREDICTEK, LLC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6791776
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; digital imaging; eye disorder; eye disorder diagnosis; human subject; imaging /visualization /scanning; iris

DESCRIPTION (provided by applicant): The objective of this project is to develop an initial prototype of a new diagnostic imaging device for use by eye care practitioners. Research in this Phase I SBIR project will focus on feasibility issues relating to technical development of the imaging instrumentation and image processing approaches required. If successful, the proposed instrument will permit visualization of eye disease in cases where detection is difficult or impossible by currently available technology. Specifically, the instrument we envision will detect, quantify, and report information obtained by multispectral imaging of the iris using visible and near-infrared transillumination (i.e., light directed through the skin, then reflected out through the iris from within the eye). Visible-light transillumination, with visual evaluation by the practitioner, is routinely used in clinical practice. However, this approach suffers from low sensitivity, especially when the subject has dark-colored irides and/or when the disease is in its early stages or is otherwise subtle. We propose that multispectral digital imaging, with automated image analysis, will be a major step forward for evaluation of diseases of the iris. The anticipated advantages of this approach lie not only in improved diagnostic performance, but also in the benefits offered by digital imaging, including automated image analysis, archiving and reporting of results, and longitudinal tracking of disease progression. The device is expected to have clinical importance for the following disorders: pigmentary dispersion syndrome and secondary glaucoma, Fuchs' heterochromic iridocyclitis, ocular albinism in infants, and iridociliary cysts.

描述（由申请人提供）： 该项目的目的是开发新的诊断成像设备的初始原型，以供眼保健从业人员使用。 I阶段I SBIR项目的研究将重点放在与成像仪器和图像处理方法的技术开发有关的可行性问题上。如果成功，则建议的仪器将在当前可用的技术难以检测或不可能的情况下可视化眼病。具体而言，我们设想的仪器将使用可见的和近二世的透明仪检测，量化和报告通过对虹膜的多光谱成像获得的信息（即，通过皮肤引导的光，然后从眼睛内部通过虹膜反射出来）。可见光的透明量和从业者的视觉评估通常用于临床实践。但是，这种方法的灵敏度低，尤其是当受试者患有深色虹彩和/或疾病处于早期阶段或其他微妙时。我们建议，具有自动图像分析的多光谱数字成像将是评估虹膜疾病的重要一步。这种方法的预期优势不仅在于提高诊断性能，还在于数字成像所提供的好处，包括自动化图像分析，归档和报告结果以及疾病进展的纵向跟踪。预计该设备对以下疾病具有临床重要性：色素色散综合征和继发性青光眼，Fuchs的异质虹膜虹膜细胞炎，婴儿的眼睛白化病和虹膜囊肿囊肿。

项目成果

Quantification of pupil parameters in diseased and normal eyes with near infrared iris transillumination imaging.

• DOI: 10.3928/15428877-20120301-02
• 发表时间: 2012-05
• 期刊: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
• 作者: D. K. Roberts;Yongyi Yang;A. Lukic;J. Wilensky;M. Wernick

Multispectral diagnostic imaging of the iris in pigment dispersion syndrome.

色素分散综合征虹膜的多光谱诊断成像。

• DOI: 10.1097/ijg.0b013e3182120877
• 发表时间: 2012
• 期刊: Journal of glaucoma
• 影响因子: 2
• 作者: Roberts,DanielK;Lukic,Ana;Yang,Yongyi;Wilensky,JacobT;Wernick,MilesN
• 通讯作者: Wernick,MilesN

Novel observations and potential applications using digital infrared iris imaging.

使用数字红外虹膜成像的新颖观察和潜在应用。

• DOI: 10.3928/15428877-20090301-18
• 发表时间: 2009
• 期刊: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
• 作者: Roberts,DanielK;Lukic,AnaS;Yang,Yongyi;Moroi,SayokoE;Wilensky,JacobT;Wernick,MilesN
• 通讯作者: Wernick,MilesN