Functional Testing and Quality of Life in Glaucoma

青光眼的功能测试和生活质量

基本信息

批准号：
10734431
负责人：
Stuart Gardiner
金额：
$ 62.8万
依托单位：
LEGACY EMANUEL HOSPITAL AND HEALTH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-30 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734431
关键词：
Activities of Daily Living Affect Blindness Caring Cellular Phone Central Scotomas Clinic Clinical Clinical Management Clinical Trials Consumption Contrast Sensitivity Custom Data Devices Disease Electronics Equilibrium Eye Fall prevention Glaucoma Goals Health Hospitalization Impairment Individual Light Light Adaptations Lighting Location Longitudinal Studies Measurement Measures Medical Motivation National Eye Institute Ocular Hypertension Outcome Measure Participant Patient Care Patient Outcomes Assessments Patient Self-Report Patient-Focused Outcomes Patients Pattern Perimetry Peripheral Persons Quality of life Questionnaires Reporting Research Risk Scotoma Severities Severity of illness Tablet Computer Tablets Testing Time Trabeculectomy Vision Visit Visual Visual Fields Visual System Work Writing clinical care equilibration disorder experience fall risk falls functional loss hypertension treatment improved indexing individual patient medication compliance novel patient oriented personalized medicine preventive intervention prospective rate of change research clinical testing treatment adherence visual search

Activities of Daily Living Affect Blindness Caring Cellular Phone Central Scotomas Clinic Clinical Clinical Management Clinical Trials Consumption Contrast Sensitivity Custom Data Devices Disease Electronics Equilibrium Eye Fall prevention Glaucoma Goals Health Hospitalization Impairment Individual Light Light Adaptations Lighting Location Longitudinal Studies Measurement Measures Medical Motivation National Eye Institute Ocular Hypertension Outcome Measure Participant Patient Care Patient Outcomes Assessments Patient Self-Report Patient-Focused Outcomes Patients Pattern Perimetry Peripheral Persons Quality of life Questionnaires Reporting Research Risk Scotoma Severities Severity of illness Tablet Computer Tablets Testing Time Trabeculectomy Vision Visit Visual Visual Fields Visual System Work Writing clinical care equilibration disorder experience fall risk falls functional loss hypertension treatment improved indexing individual patient medication compliance novel patient oriented personalized medicine preventive intervention prospective rate of change research clinical testing treatment adherence visual search

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项目摘要

Project Summary / Abstract The goal of clinical management in eye care is to protect patients’ vision and consequent quality of life. Yet, the impact of vision loss on an individual’s quality of life depends not only on its severity, but also on its location within the visual field. Some tasks are predominantly impacted by central visual field loss, while others rely more on differing regions of the peripheral visual field. Thus, two individuals with the same disease severity could have very different experiences of that loss. This is particularly true for glaucoma, which causes localized loss in locations that can differ greatly between individuals. In this project, we will determine the regions of the visual field that most influence different aspects of quality of life. We will derive quantitative metrics of the likely real- world effects of an individual patient’s visual field defect that can be obtained without relying on time-consuming and variable questionnaires. These patient-centered metrics can aid clinicians in prioritizing care and choosing appropriate management strategies; and in explaining to an individual patient what the likely consequences are of their disease, both as motivation to maintain medication adherence and so that they can make necessary adjustments to their activities of daily living. In Aim 1, we will derive indices predicting the effect of an individual’s visual field loss on different patient-reported outcome measures, by parameterizing results from clinical standard automated perimetry, to maximize correlations with results of patient questionnaires from four large studies of ocular hypertension and glaucoma. In Aim 2, we will use similar analyses to predict the impact on visual search as measured by a custom-written test, performed on a tablet computer in glaucoma clinic waiting rooms and testing rooms. In Aim 3, we will predict the impact of an individual’s visual field loss on the visual contribution to balance and subsequent risk of falling, using objective measurements of balance in both high and low ambient light settings. Overall, the project will provide substantial advances in our understanding of the effects of localized visual field loss as caused by glaucoma, and provide invaluable new information for clinicians and patients.

项目摘要 /摘要眼保健中临床管理的目的是保护患者的视力和随之而来的生活质量。但是，视力丧失对个人生活质量的影响不仅取决于其严重性，而且还取决于其位置在视野内。某些任务主要受到中央视野损失的影响，而另一些任务则更多在外围视野的不同区域。那是两个患有相同疾病严重程度的人这种损失的经历截然不同。对于青光眼尤其如此，这会导致局部损失个人之间可能有很大差异的位置。在这个项目中，我们将确定视觉的区域影响生活质量不同方面的领域。我们将得出可能实现的定量指标单个患者视野缺陷的世界影响，可以在不依靠时必时间的情况下获得和可变问卷。这些以患者为中心的指标可以帮助临床医生优先考虑护理和选择适当的管理策略；并向单个患者解释可能的后果是什么他们的疾病，都是维持药物依从性的动力，以便他们可以做到必要调整其日常生活活动。在AIM 1中，我们将得出预测个人效果的指数通过从临床标准的参数化结果，对不同患者报告的结果指标的视野损失自动化周期性，以最大程度地与四个大型研究的患者问卷的结果相关眼高血压和青光眼。在AIM 2中，我们将使用类似的分析来预测视觉搜索的影响通过定制编写的测试测量，在青光眼诊所候诊室的平板电脑上执行测试室。在AIM 3中，我们将预测个人视野损失对视觉贡献的影响在高和低环境中使用客观测量平衡的平衡和随后的风险灯光设置。总体而言，该项目将在我们对本地化影响的理解方面提供重大进展视野损失是由青光眼引起的，并为临床医生和患者提供了宝贵的新信息。