Eye Movement Rehabilitation in Low Vision Patients

低视力患者的眼动康复

• 批准号: 10362666
• 负责人: Peter John Bex
• 金额: $ 35.86万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10362666
• 关键词: Activities of Daily Living; Affect; Age; American; Awareness; Basic Science; Behavior; Blindness; Clinical; Computers; Contrast Sensitivity; Control Locus; Coupling; Cues; Development; Disease; Disease Progression; Economics; Eye; Eye Movements; Eye diseases; Feedback; Goals; Hand; Health; Impairment; Lead; Learning; Location; Low Prevalence; Mental Depression; Methods; Motor; Movement; New England; Optometry; Pathologic; Patients; Pattern; Performance; Persons; Psychophysics; Public Health; Quality of life; Questionnaires; Reading; Rehabilitation therapy; Research; Residual state; Resolution; Retina; Retinal blind spot; Saccades; Scientist; Scotoma; Sensory; Series; Services; Smooth Pursuit; Standardization; System; Television; Time; Training; Translating; Universities; Vision; Visual; Visual Acuity; Visual impairment; Visual system structure; base; clinical application; college; evidence base; experience; eye hand coordination; fovea centralis; functional outcomes; gaze; improved; interest; macula; mortality; oculomotor; rehabilitation strategy; sample fixation; social; visual feedback; visual tracking

Project Summary/ Abstract Approximately 217 million people worldwide currently suffer from low vision, which impact a broad range of activities of daily living and is associated with depression and increased mortality. Over half of the patients presenting for low vision services have eye disease that affects the fovea and surrounding macula and leads to central vision loss (CVL). People with CVL are forced to use eccentric vision as a substitute for their impaired fovea, however eye movement control and visual function is impaired with eccentric vision. This proposal brings together basic and clinical vision scientists at Northeastern University, the Lighthouse Guild and New England College of Optometry in order to help people with CVL to learn to use their remaining vision more effectively. Recent evidence shows that rehabilitation methods can help improve oculomotor control and this can lead to improved functional outcomes. We have developed new feedback-based methods that aim to improve eccentric vision training in patients with CVL. In a series of studies we examine rehabilitation of fixation control, smooth pursuit eye movements that track moving objects and saccadic eye movements that abruptly change the point of regard. We examine how visual feedback, scotoma awareness methods and hand-eye coordination can improve eccentric vision usage. Improvements in oculomotor control are quantified with eye tracking methods and associated changes in visual function are quantified with acuity, contrast sensitivity and reading performance. The proposed research therefore develops and translates state-of-the-art methods in basic science to clinical applications. Accomplishing the proposed aims will provide new and improved methods for rehabilitation strategies for visual impairment. The ultimate goal of this proposal is to maximize the residual visual function of people with low vision and to help them to live independently, thereby improving quality of life and minimizing the economic and social burden of visual impairment.

项目摘要/摘要 目前，全球约有2.17亿人患有低视力，这影响了广泛的 日常生活的活动，与抑郁症和死亡率增加有关。超过一半的患者 低视力服务的呈现具有影响中央凹和周围黄斑的眼睛疾病，并导致 中央视力损失（CVL）。 CVL患者被迫使用古怪的视觉代替他们的受损 fovea，无论眼动控制和视觉功能受到偏心视力而受损。这个建议 汇集了东北大学，灯塔公会和新的基本和临床视觉科学家 英格兰验光学院，以帮助CVL的人学习更多的愿景 有效地。 最近的证据表明，康复方法可以帮助改善动眼控制，这可能导致 改善功能结果。我们开发了新的基于反馈的方法，旨在改善 CVL患者的偏心视力训练。在一系列研究中，我们检查了固定的康复 控制，光滑的追击眼动动作，跟踪移动物体和saccadic眼动动作 突然改变关注点。我们研究视觉反馈，Scotoma意识方法和 手眼协调可以改善偏心的视力使用情况。动眼控制的改进是 用眼睛跟踪方法和视觉功能的相关变化量化，用敏锐度量化 对比敏感性和阅读性能。 因此，拟议的研究将基础科学的最先进方法发展为临床 申请。完成拟议的目标将为康复提供新的和改进的方法 视觉障碍的策略。该提案的最终目标是最大化 有视力低下并帮助他们独立生活的人，从而改善生活质量并最大程度地减少 视觉障碍的经济和社会负担。