MICROCOIL NMR: EXTENDING FIELD LIMITS OF HIGH RESOLUTION

微线圈核磁共振：扩展高分辨率的场限制

• 批准号: 6951718
• 负责人: TIMOTHY L PECK
• 金额: $ 30万
• 依托单位: PROTASIS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951718
• 关键词: bioimaging /biomedical imaging; contrast media; image enhancement; magnetic field; nuclear magnetic resonance spectroscopy; radiation detector; technology /technique development

DESCRIPTION (Verbatim from Applicant's Abstract): The overall goal of this study is to extend the present upper field limits of NMR spectroscopy by using the scaling advantages of NMR microcoils, and therefore enable for the first time the use of very narrow bore magnets of the highest field strength currently attainable coupled to custom NMR probes of the highest mass sensitivity currently attainable. This unique and powerful combination of magnet and probe technology for increased NMR sensitivity also provides inherent cost advantages. The potential impact of this advance on the otherwise exponential performance vs. cost barrier of high field, high resolution NMR is to substantially lower expenses of such systems by factor of 5-10. The proposed research will serve as a demonstration of feasibility for subsequent commercialization that offers to bring high field NMR into common use in a relatively rapid time frame in commercial, academic, and government laboratories. NIH support will enable research assessment of the primary technology factors required to carry out subsequent commercialization, and will facilitate a first step in a direction for technology development explicitly defined as one of national significance. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（逐字研究来自申请人的摘要）：此的总体目标 研究是通过使用NMR光谱的当前高场限制 NMR Microcoils的缩放优势，因此可以为第一个启用 时间使用非常狭窄的最高磁场磁铁 目前可实现的耦合与最高质量的自定义NMR探针 目前可以达到敏感性。这种独特而有力的组合 磁铁和探测技术提高了NMR敏感性 固有的成本优势。这一进步对否则的潜在影响 指数性能与高场的成本障碍，高分辨率NMR为 以5-10倍的限制，大大降低了此类系统的费用。提议 研究将证明随后的可行性 提出将高领域NMR带入共同用途的商业化 商业，学术和政府的时间范围相对较快 实验室。 NIH支持将使主要的研究评估 进行随后的商业化所需的技术因素，并将 明确促进技术发展方向的第一步 被定义为国家意义之一。 拟议的商业应用程序：不可用