Cocaine-induced Place Preference using Virtual Reality

使用虚拟现实可卡因诱导的地点偏好

• 批准号: 7140298
• 负责人: ROBERT S ASTUR
• 金额: $ 14.11万
• 依托单位: HARTFORD HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7140298
• 关键词: adult human (21+); behavioral /social science research tag; clinical research; cocaine; computer human interaction; computer simulation; conditioning; craving; drug addiction; galvanic skin response; heart rate; human subject; preference; questionnaires; substance abuse related behavior

DESCRIPTION (provided by applicant): The purpose of this experiment is to use virtual reality to establish place preferences to cocaine in humans. Specifically, we will examine how human preferences change after administering cocaine in one of two distinct virtual reality environments. Once this groundwork is established for studying contextual effects on drug use using virtual reality, we can propose Stage II studies that examine how various medications block the acquisition and/or retrieval of preferences for places where drugs were obtained. In addition, we would use the results of the current experiment to design State II studies that use functional magnetic resonance imaging to determine the brain circuits involved in various types of drug use and abuse. The specific aims of the proposed research are as follows: 1) To determine whether humans will display a conditioned place preference to cocaine in a virtual environment. 2) To determine whether physiological measures (e.g. heart rate and galvanic skin response) will indicate increased arousal in a drug-free environment that was previously paired with cocaine. This serves as a nonverbal measure of arousal. 3) To determine whether a verbal measure of cravings, the Visual Analogue Scale (VAS), will indicate that subjects show a greater craving for cocaine in a drug-free environment that was previously paired with cocaine. 4) To determine whether individuals who are cocaine-dependent show stronger place preferences, stronger physiological measures, and higher craving measures than individuals who are recreational users of cocaine.

描述（由申请人提供）：本实验的目的是使用虚拟现实来建立对人类可卡因的偏好。具体而言，我们将研究人类偏好在两个不同的虚拟现实环境之一中管理可卡因后如何变化。一旦建立了用于使用虚拟现实研究对药物使用的上下文影响的基础，我们就可以提出II期研究，以研究各种药物如何阻止获得获得药物的偏好的获取和/或检索。此外，我们还将使用当前实验的结果来设计使用功能磁共振成像的状态II研究，以确定参与各种药物使用和滥用的脑电路。 拟议研究的具体目的如下： 1）确定人类是否会在虚拟环境中表现出对可卡因的条件地点偏好。 2）确定生理措施（例如心率和电能皮肤反应）是否表明在以前与可卡因配对的无药物环境中唤醒。这是一种非语言的唤醒度量。 3）为了确定对渴望的口头量度，视觉模拟量表（VAS）是否会表明受试者在以前与可卡因配对的无药物环境中对可卡因的渴望更大。 4）确定与可卡因的个人相比，与可卡因的娱乐用户相比，是否具有可卡因的个人是否表现出更强的地位偏好，更强的生理措施和更高的渴望措施。