ORAL CANCER DETECTION: CURRENT/EMERGING TECHNIQUES

口腔癌检测：当前/新兴技术

• 批准号: 7249317
• 负责人: DAVID A SIROIS
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7249317
• 关键词: adult human (21+); bioimaging /biomedical imaging; biomarker; biopsy; cancer risk; clinical research; cooperative study; data collection methodology /evaluation; diagnosis design /evaluation; diagnosis quality /standard; digital imaging; early diagnosis; exfoliative cytology; histopathology; human subject; longitudinal human study; neoplasm /cancer diagnosis; oral mucosa; oral pharyngeal neoplasm; outcomes research; pathologic process; polymerase chain reaction; preneoplastic state; prognosis; saliva; statistics /biometry

The stage of cancer at the time of treatment is the most important factor affecting treatment outcome: early diagnosis is associated with more than a 75% 5-year survival rate whereas late diagnosis is associated with less than a 25% 5-year survival. While survival rates for many cancers have improved during the past twenty years, the survival rate for oral cancer has remained unchanged because most cases are diagnosed at advanced stages. The natural history of oral cancer is such that the asymptomatic, pre-malignant lesion can be identified long before malignant transformation if individuals are properly evaluated and adequate assessment technology exists to support the diagnostic process. The unaided clinical examination alone is inadequate for detecting early oral cancer, even when performed by experienced clinicians, and ultimately will require adjuvant assessment tests to improving early detection. As recommended in Objective 9.6 of Healthy People 201 0 earlier detection is essential to improve treatment outcomes for oral cancer. Earlier detection will require technologies that improve visualization of, or surveillance for, early mucosal changes associated with dysplasia or malignancy, combined with diagnostic tests which accurately characterize the malignancy potential. This project will systematically examine selected current and/or emerging technologies to determine their utility and optimal application, alone or in combination, to reliably detect oral cancer / pre-cancer at its earliest stage by applying the tests to low-risk, high-risk and known oral cancer lesions. Unlike previous studies this project will allow every subject and lesion to be exposed to every assessment test, with specific attention to populations with varying risk for oral cancer and to the intended use of a test as a screening, surveillance, adjuvant or definitive diagnostic tool. The inclusion in this study of emerging technologies will facilitate the analytical validation of tests which could revolutionize the detection and diagnosis of oral cancer. It is expected that insights gained from this study will be hypothesis-provoking, leading to new ideas about biomarkers for oral cancer and their exploitation for the prevention, early detection and treatment of oral cancer.

治疗时癌症的阶段是影响治疗结果的最重要因素： 早期诊断与超过75％的5年生存率有关，而晚期诊断则相关 不到25％的5年生存。虽然过去许多癌症的存活率在过去有所提高 二十年，口腔癌的存活率一直保持不变，因为大多数病例都被诊断出 高级阶段。口腔癌的自然病史使得无症状的恶性病变可以是 如果对个人进行了适当的评估和足够的评估，则在恶性转化之前很久就确定 技术存在以支持诊断过程。仅无助的临床检查就不足 即使是由经验丰富的临床医生进行的，也检测到早期口腔癌，最终将需要 辅助评估测试以改善早期检测。根据目标9.6的健康人的建议 201 0早期检测对于改善口腔癌的治疗结果至关重要。较早的检测需要 改善与发育不良相关的早期粘膜变化的可视化或监视的技术 或恶性肿瘤，再加上诊断测试，这些测试准确地表征了恶性潜力。 该项目将系统地检查选定的当前和/或新兴技术以确定 它们的实用性和最佳应用，单独或合并，可靠地检测到口腔癌 /前癌症 最早的阶段通过将测试应用于低风险，高危和已知的口腔癌病变。与以前的研究不同 该项目将允许每个主题和病变都暴露于每项评估测试中，并特别注意 口腔癌风险不同的人群以及预期使用测试作为筛查，监视， 辅助或确定的诊断工具。这项新兴技术研究的纳入将有助于 对可能彻底改变口腔癌检测和诊断的测试的分析验证。预计 从这项研究中获得的见解将是引人入胜的，导致有关生物标志物的新想法 口腔癌及其对预防，早期检测和治疗口腔癌的剥削。