Optical Spectroscopy for Management of Cancer Treatment

光谱用于癌症治疗管理

• 批准号: 7124693
• 负责人: IRVING J. BIGIO
• 金额: $ 120.12万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124693
• 关键词: clinical research; cooperative study; human subject; neoplasm /cancer photoradiation therapy; spectrometry

DESCRIPTION (provided by applicant): The goal of this Team is the clinical application of the methods of Optical Pharmacokinetics (OP) and Elastic Scattering Spectroscopy (ESS) for the management of photodynamic therapy (PDT) in the treatment of cancer and other pathologies. OP will be used to monitor local tissue concentrations andbiodistribution of PDT agents, providing patient-specific information on dosage and optimal time foractivation. ESS will be used as an adjunct to follow the response of tissues to treatment by sensingchanges in the tissue optical properties. The short-term objectives are to detect and resolve any limitations for clinical implementation, to demonstrate that these are clinically "friendly" modalities, and to generate the computational/numerical tools that will provide the measured results in real time during clinical treatment. The ideal implementation of PDT requires delivery of both the proper drug dosage and the proper light "dosage", which in turn requires understanding of the optical properties of the tissue and knowledge of drug concentration in the tissue of interest. In vivo measurements would provide information on patient-patient variability in the uptake of the drug and, therefore, make possible individual dosimetry for PDT. In addition, the site-specific time history of the drug is especially important because the photoactivation should be done when the ratio of drug concentration in the tumor to surrounding tissue is at a maximum. The Primary Projects address both animal and clinical studies to answer a series of questions aimed at validating the capabilities and sensitivities of the spectroscopic methods and assessing the implications of those aspects of the methods that impact clinical utility and health-care significance. The Technical Support Core-provides-the-instrumentation-and the mathematical tools to all Projects and facilitates the data analysis. The Administrative Core provides the superstructure of the Team, especially to facilitate communication and information sharing, both within this Team and among all the Teams of the Network.

描述（由申请人提供）：该团队的目标是光学药代动力学方法（OP）和弹性散射光谱（ESS）的临床应用，用于治疗癌症和其他病理学。 OP将用于监测PDT药物的局部组织浓度和生物分配，从而提供有关剂量和最佳时间诱导的患者特定信息。 ESS将被用作辅助，以遵循组织光学特性中的传感变成组织对处理的响应。短期目标是检测并解决临床实施的任何局限性，以证明这些局限性是临床上“友好”的方式，并生成计算/数值工具，这些工具将在临床治疗期间实时提供测量结果。 理想的PDT实现需要同时递送适当的药物剂量和适当的光剂量“剂量”，进而需要了解组织中组织的光学特性以及对感兴趣组织中药物浓度的知识。体内测量值将提供有关药物摄取中患者患者可变性的信息，因此可以使PDT的单个剂量法。此外，该药物的特定部位时间历史尤其重要，因为当肿瘤中的药物浓度与周围组织的比率最大时，应进行光活化。 主要项目涉及动物和临床研究，以回答一系列旨在验证光谱方法的能力和敏感性的问题，并评估影响临床实用性和医疗保健意义的方法的含义。技术支持核心启发性和用于所有项目的数学工具，并促进了数据分析。行政核心提供了团队的上层建筑，尤其是为了促进该团队和网络所有团队中的沟通和信息共享。