Natural History of Borrelia lonestari

孤独疏螺旋体的自然历史

基本信息

批准号：
7211134
负责人：
SUSAN E LITTLE
金额：
$ 34.18万
依托单位：
OKLAHOMA STATE UNIVERSITY STILLWATER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7211134
关键词：
Borrelia human infection model ticks

项目摘要

DESCRIPTION (provided by the applicant): Southern tick-associated rash illness (STARI) is a newly-described Lyme disease-like infection reported from the southeastern and south central United States caused by Borrelia Ionestari. Our long-range goal is to understand the risk factors that conspire to allow maintenance of tick-borne bacterial pathogens in nature and transmission of these pathogens from the reservoir host-tick vector maintenance cycle to people. As our next objective in pursuit of this goal, we propose in this application to delineate the natural history of Borrelia Ionestari. Our central hypothesis is that Borrelia Ionestari is maintained in nature through a cycle involving white-tailed deer as primary reservoir host and lone star ticks as predominant vector, and that this system can be exploited to develop a geographic information system (GIS)-based model that predicts areas where humans are at greatest risk of infection. The rationale behind the proposed research is that field and experimental infection data collected to date indicate infection with Borrelia Ionestari is maintained in a deer-lone star tick reservoir system. To accomplish the objectives of this application, we will pursue four specific aims: (1) confirm that Borrelia Ionestari is maintained in a cycle involving white-tailed deer as reservoir host and lone star ticks as vector; (2) define the geographic distribution of Borrelia Ionestari in the United States using white-tailed deer as sentinels and lone star ticks as confirmatory indicators of the presence of infection in an area; (3) identify other potential wild vertebrate reservoir hosts and tick vectors that may be involved in the natural history of Borrelia Ionestari; and (4) evaluate rodents as a potential model for experimental infection with Borrelia Ionestari. At the completion of this research, we expect to have fully delineated the natural history of Borrelia Ionestari We also expect to have defined the geographic distribution of this pathogen in a manner that both examines the landscape epidemiology of this organism in detail and allows identification of areas where risk of human infection is high. Ultimately, the model of the natural history of Borrelia Ionestari gained from the proposed research will improve understanding of both STARI and Lyme borreliosis in the southern U.S., enhancing public health efforts in those areas where people are risk of infection; reduction in human disease from these pathogens should result.

描述（由申请人提供）：南部tick相关的皮疹疾病（STARI）是由Borrelia ionestari引起的美国东南部和中南部报道的新描述的类似莱姆病的感染。我们的远距离目标是了解促进自然界中tick传播细菌病原体的危险因素，并将这些病原体从储层宿主宿主及其传播传播给人们。作为追求这一目标的下一个目标，我们在此应用中建议描述伯罗利亚岛的自然历史。我们的中心假设是，通过涉及白尾鹿作为主要储层宿主和孤星的循环，在本质上保持了伯氏离子，并且可以利用该系统来开发该系统以开发地理信息系统（GIS）的模型，以预测人类具有最大风险感染风险的区域。拟议的研究背后的理由是，迄今为止收集的现场和实验感染数据表明，在鹿孤独的恒星tick储库系统中维持了伯氏骨的感染。为了实现此应用程序的目标，我们将追求四个具体的目标：（1）确认Borrelia ionestari被保持在涉及白尾鹿作为储层宿主的周期中，而孤星则是向量；（2）定义美国在美国的地理分布，使用白尾鹿作为哨兵和孤星tick虫，作为某个地区存在感染的确认指标；（3）确定其他潜在的野生脊椎动物储存器和可能参与Borrelia ionestari自然历史的壁虱载体；（4）将啮齿动物评估为渗漏伯氏离子estari实验感染的潜在模型。这项研究完成后，我们预计我们还希望以详细研究这种生物体的景观流行病学的方式来确定这种病原体的地理分布，并允许确定人类感染的风险很高。最终，从拟议的研究中获得的伯氏疏螺旋体的自然历史模型将改善对美国南部Stari和Lyme Borreliosis的理解，从而在人们处于感染风险的地区加强了公共卫生的努力；这些病原体应减少人类疾病。