Ontario Registry for Studies of Familial Colon Cancer

安大略省家族性结肠癌研究登记处

• 批准号: 6951493
• 负责人: STEVEN GALLINGER
• 金额: $ 197.73万
• 依托单位: CANCER CARE ONTARIO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951493
• 关键词: Canada; cancer information system; cancer registry /resource; cancer risk; clinical research; colorectal neoplasms; cooperative study; data management; family genetics; genetic susceptibility; human subject; neoplasm /cancer epidemiology; neoplasm /cancer genetics; patient oriented research; tissue resource /registry

DESCRIPTION (provided by applicant): This is a continuation application by the Ontario Familial Colorectal Cancer Registry (OFCCR), an active member of the Cooperative Family Registries for Colorectal Cancer Studies (CFR), to complete, maintain, update and expand our infrastructure of data and biospecimens, for current and future collaborative studies in the broad area of colorectal cancer research. Over the past four years, the OFCCR has collected family history data, personal risk factor and food frequency information, blood and tumor samples from over 1,300 incident colorectal cancer cases identified by the Ontario Cancer Registry, using common protocols developed by the 6 CFR centers. We are also collecting similar data from over 4,000 relatives of the aforementioned probands and about 900 age and sex-matched (to the probands) population controls. This large infrastructure will now be augmented for further collaborative genetic studies by: 1) accruing incident colorectal cancer cases less than age 50 in Ontario (and family members) from 2003 to 2007; 2) registering and expanding prevalent high risk colorectal cancer kindreds from the Familial GI Cancer Registry in Toronto, and 3) enhancing a newly formed collaboration with colleagues in Newfoundland who are developing a similar family-based colorectal cancer registry. In addition, the OFCCR, in cooperation with the CFRs, will develop and implement both active and passive follow-up protocols for existing and newly recruited subjects as well as family members. These activities will ensure the maintenance of a high quality, and up-to-date family registry which will be used both locally, and in collaboration with other scientists, in studies of gene-gene interactions, gene-environment interactions, genetic epidemiology, pharmacogenomics, gene discovery, psychosocial and behavioral research. The OFCCR will also be a rich resource of high-risk subjects for future recruitment into colorectal cancer prevention trials.

描述（由申请人提供）： 这是安大略族家庭大肠癌登记册（OFCCR）的延续应用，他是结直肠癌研究（CFR）合作家庭注册机构（CFR），以完成，维护，更新和扩展我们的数据和生物测量基础结构，用于在大型结构癌症研究领域的当前和未来协作研究。在过去的四年中，OFCCR收集了家庭历史数据，个人风险因素和食物频率信息，血液和肿瘤样本，使用了由6个CFR中心开发的常见方案，来自安大略省癌症注册中心确定的1,300多个事件的结直肠癌病例。我们还从上述证据的4,000多个亲戚那里收集类似的数据， 大约900岁的年龄和性别匹配（对可能的）人口控制。现在，该大型基础设施将通过：1）在2003年至2007年期间在安大略省（和家庭成员）的50岁小于50岁以下的事件遗传研究进行进一步的合作遗传研究； 2）在多伦多的家族性GI癌症注册表中注册并扩大了普遍的高风险大型结直肠癌，3）加强与纽芬兰的同事新成立的合作，他们正在开发类似的家庭结直肠癌注册表。此外，OFCCR与CFR合作将为现有和新招聘的受试者以及家庭成员制定和实施主动和被动的后续方案。这些活动将确保维持高质量和最新的家庭注册中心，该注册表将在本地使用，并与其他科学家合作，研究基因 - 基因相互作用，基因 - 环境相互作用，遗传流行病学，药物基因组学，基因发现，心理社会和行为研究。 OFCCR也将是丰富的资源 高风险受试者将来招募结直肠癌预防试验。