ONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCER

安大略省家族性结肠癌研究登记处

• 批准号: 2896022
• 负责人: STEVEN GALLINGER
• 金额: $ 83.28万
• 依托单位: CANCER CARE ONTARIO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2896022
• 关键词: Canada; cancer information system; cell bank /registry; clinical research; colon neoplasms; cooperative study; family genetics; human subject; patient /disease registry

DESCRIPTION: (Applicant's Description) The general objective of this application is to develop a population-based colorectal cancer (CRC) family registry resource, with epidemiologic data and a biologic tissue bank, from CRC patients in Ontario, Canada. The registry will be a contributor to the consortium of such registries planned by the National Institutes of Health (NIH) that will be used for epidemiologic studies, primary prevention trials, gene discovery; for the investigation of gene environment interactions; and for the evaluation of surveillance protocols and treatment interventions in high risk CRC families as part of a Co-operative Agreement with other family registries. This objective will be met by building on existing infrastructure and experience developed by co-investigators participating in the activities of the previously awarded Co-operative Family Registry for Breast Cancer Studies (CFRBCS), with which the CRC registry proposed here will be integrated. Further, the proposed Co-operative Family Registry for Colon Cancer Studies (CFRCCS) will take advantage of established resources, in particular the Ontario Cancer Genetics Network (OCGN) and the population-based Ontario Cancer Registry (OCR). The applicant plans to compile family history data for all eligible CRC cases in Ontario who will serve as probands, and family history information will be used to define cohorts of high risk according to the Amsterdam criteria and intermediate risk and sporadic cases and their families. Epidemiologic data, CRC treatment data and biologic tissues will be obtained from all high and intermediate risk probands and their families, from a random sample of sporadic cases (and a subsample of their families), and from population controls and a sample of their families. The frequency and nature of mutations in genes involved in hereditary predisposition to colon cancer in high and intermediate risk families will be determined. Molecular diagnostic testing will be performed on specimens from probands in these risk groups. The populations with hereditary predisposition to CRC identified by these activities will be potential participants in trials that evaluate new prevention and therapeutic strategies.

描述：（申请人的描述） 该应用的一般目标是开发基于人群的 结直肠癌（CRC）家庭注册资源，以及流行病学数据 以及加拿大安大略省CRC患者的生物组织库。 这 注册表将成为计划注册机构的财团的贡献者 由美国国立卫生研究院（NIH） 流行病学研究，初级预防试验，基因发现；为了 研究基因环境相互作用；以及评估 高风险CRC家族的监视方案和治疗干预措施 作为与其他家庭登记处的合作协议的一部分。 通过建立现有基础设施和 共同投资者开发的经验参与活动 先前授予的乳腺癌的合作家族注册表 研究（CFRBC），此处提出的CRC注册表将是 融合的。 此外，拟议的结肠家庭注册表 癌症研究（CFRCC）将利用既定资源 特别是安大略省癌症遗传学网络（OCGN）和 基于人群的安大略省癌症注册中心（OCR）。 申请人计划 在安大略省所有合格的CRC案件中编译家族史数据 用作概率，家族史信息将用于定义 根据阿姆斯特丹的标准和中间的高风险人群 风险和零星案件及其家人。 流行病学数据，CRC 将从所有高和生物组织中获得的治疗数据和生物组织 从随机样本的中间风险概率及其家人 零星的病例（以及家人的子样本），人口 控制和家人样本。 遗传基因突变的频率和性质 在高和中级风险家族中对结肠癌的易感性将 可以确定。 分子诊断测试将在样品上进行 来自这些风险群体中的概率。 人群与世袭 这些活动确定的CRC易感性将是潜在的 评估新预防和治疗的试验参与者 策略。