Ontario Registry for Studies of Familial Colon Cancer

安大略省家族性结肠癌研究登记处

基本信息

批准号：
7486430
负责人：
STEVEN GALLINGER
金额：
$ 160.75万
依托单位：
CANCER CARE ONTARIO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-30 至 2008-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7486430
关键词：
8q24 Age Bioinformatics Blood specimen Calibration Canada Chemoprevention Clinic Colon Colon Carcinoma Colorectal Cancer Communities Consent Cooperative Family Registry Data Data Collection Diagnosis Disease Enrollment Epidemiology Family Family history of Family member Fostering Freezing Future Gene Mutation General Hospitals Genes Genetic Markers Genomics Genus Cola Hawaii Hospitals Human Herpesvirus 4 Informatics Malignant neoplasm of gastrointestinal tract Methods Minor Minority Mismatch Repair Molecular Mutation Newfoundland Newly Diagnosed Ontario PAWR gene Participant Penetrance Phase Pilot Projects Population Population Registers Population-Based Registry Predisposition Province Psychosocial Assessment and Care Public Health Questionnaires Recruitment Activity Registries Relative (related person)Research Research Infrastructure Research Personnel Resources Risk Risk Factors Sampling Serum Site Testing Tissues base case control follow-up genetic risk factor genome wide association study member mutation carrier neoplasm registry novel proband psychosocial repository tumor

项目摘要

{\rtf1\ansi\ansicpg1252\deff0\deflang1033{\fonttbl{\f0\fswiss\fcharset0 Arial;}} {\*\generator Msftedit 5.41.15.1515;}\viewkind4\uc1\pard\f0\fs21 The Ontario Familial Colorectal Cancer Registry (OFCCR) is a productive member of the multinational six\par site Colon Cooperative Family Registries (Colon CFR). During Phases I and II (1997-2007), the OFCCR\par registered population based subjects, with family history data, epidemiologic risk factor data, dietary data,\par and biospecimens (blood, serum, tumor blocks) for over 4,8,00 incident colorectal cancer (CRC) cases, their\par 4,000 relatives, as well as similar data for over 1,900 controls from the province of Ontario, Canada. The\par OFCCR has contributed approximately one-quarter of all CFR cases, and half the CFR-wide population\par controls. The OFCCR biospecimen repository (BSR) at Mount Sinai Hospital (MSH) in Toronto maintains\par and distributes to the scientific community genomic germline DMA from OFCCR cases and controls, all of\par which have been EBV transformed to protect this valuable resource. During Phase II, the OFCCR recruited\par additional high risk families from the clinic-based Familial Gastrointestinal Cancer Registry at MSH; 75\par germline mismatch repair (MMR) gene mutation carriers and their relatives are now available for penetrance,\par epidemiologic, chemoprevention, psychosocial, and other research aimed at understanding familial and\par sporadic CRC. The OFCCR also contributed to the CFR, over 200 fresh frozen tumor samples, with\par annotated family history, epidemiologic and clinicopathologic data. Other unique contributions of the OFCCR\par to the Colon CFR include; germline MYH mutation testing of all Colon CFR cases and controls and the first\par genome wide association study in CRC that identified 8q24 SNPs that predict CRC susceptibility. In the\par current application (Phase III), the OFCCR proposes to continue as an active registry of the Colon CFR with\par the following Specific Aims: 1) expanding OFCCR families with MMR gene mutations, 2) recruiting additional\par high risk families from across Canada, 3) maintaining contact and follow-up of over 5,000 participants, 4)\par obtaining clinicopathologic and first treatment data on Phase I, II and III cases, 5) collaborating with the\par Colon CFR in molecular characterization of about 2,900 OFCCR cases (OFCCR will continue to test Colon\par CFR cases for MYH mutations), 6) adding to, and maintaining the OFCCR BSR and coordinating future\par efforts with the Colon CFR Central Repository, 7) maintaining the OFCCR bioinformatics core and\par coordinating efforts with RTI, the Informatics Center for the Colon CFR, 8) maintaining the OFCCR\par administrative core and contributing to the continued administrative efforts of the Colon CFR.\par The Colon CFR is the largest resource of its kind worldwide. Public health contributions of the OFCCR and\par the Colon CFR in general are far reaching including; providing a better understanding of susceptibility to\par CRC, identifying novel genetic markers of this disease, characterizing gene x gene and gene x\par environmental associations, and fostering clinicopathologic and psychosocial studies.\fs20\par \par }

{\ rtf1 \ ansi \ ansicpg1252 \ deff0 \ deflang1033 {\ fonttbl {\ f0 \ f0 \ f0 \ fswiss \ fCharSet0 arial;}}} {\*\ Generator msftedit 5.41.15.1515;} \ viewKind4 \ uc1 \ pard \ f0 \ f0 \ f0 \ fs21 Ontario家族性大肠癌注册表（OFCCR）是跨国公司六\ PAR的生产力成员现场结肠合作家庭注册（COLON CFR）。在第I和II阶段（1997-2007）期间，Ofccr \ par 注册的基于人群的受试者，具有家族史数据，流行病学风险因素数据，饮食数据，\ par 超过4,8,00个大肠癌（CRC）病例的生物测量（血液，血清，肿瘤块），其\ par 来自加拿大安大略省的1,900多个控制的4,000名亲戚以及类似的数据。 \ par OFCCR在所有CFR案件中贡献了大约四分之一，而CFR范围\ PAR的一半控件。多伦多的Sinai Mount Hospital（MSH）的OFCCR Biospecemecimen仓库（BSR）维持\ par 并从OFCCR病例和对照中分发给科学界基因组种系DMA 经过EBV转换以保护这一宝贵资源。在第二阶段，OFCCR招募\ par 来自MSH的基于诊所的家族性胃肠道癌注册中心的其他高风险家庭； 75 \ par 种系不匹配维修（MMR）基因突变携带者及其亲属现已可用于渗透率，\ par 流行病学，化学预防，社会心理和其他旨在了解家族和\ par的研究零星CRC。 OFCCR还为CFR贡献了200多个新鲜的冷冻肿瘤样品，\ par 注释的家族病史，流行病学和临床病理学数据。 Ofccr \ par的其他独特贡献到结肠CFR包括；所有结肠CFR病例和对照的种系MYH突变测试以及第一个\ par 在CRC中，基因组广泛的关联研究确定了预测CRC敏感性的8q24 SNP。在\ par中当前应用（第三阶段），OFCCR建议继续作为\ par的结肠CFR的主动注册表以下具体目的：1）扩大MMR基因突变的CCR家族，2）招募其他\ par 来自加拿大各地的高风险家庭，3）维持5,000多名参与者的接触和随访，4）\ par 在I期，II和III案例上获取临床病理学和第一次治疗数据，5）与\ par合作结肠CFR分子表征约2900例OFCCR病例（OFCCR将继续测试结肠\ PAR MYH突变的CFR案例），6）添加并维护OFCCR BSR并协调未来\ par 与COLON CFR中央存储库的努力，7）维护OFCCR生物信息学核心和\ par 与RTI的协调努力，结肠CFR信息中心，8）维护OFCCR \ par 行政核心，并为结肠CFR的持续行政工作做出贡献。\ par 结肠CFR是全球范围内最大的资源。 OFCCR和\ par的公共卫生贡献一般来说，结肠CFR的到来包括：提供对\ par的易感性的更好理解 CRC，识别这种疾病的新遗传标记，表征基因X基因和基因X \ PAR 环境协会，并培养临床病理学和社会心理研究。\ fs20 \ par \ par }