Auditory-Vocal Interaction Mechanisms

听觉-声音交互机制

• 批准号: 6922930
• 负责人: XIAOQIN WANG
• 金额: $ 37.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6922930
• 关键词: Callithricidae; Primates; action potentials; auditory cortex; auditory feedback; behavior test; behavioral /social science research tag; biological models; computer program /software; fluorescence microscopy; growth /development; hearing disorders; immunocytochemistry; microelectrodes; neural information processing; neuroanatomy; neurobiology; neurophysiology; neuroregulation; ototoxin; sound perception; telemetry; vocalization

DESCRIPTION (provided by applicant): The objective of the proposed research is to understand physiological mechanisms underlying auditory-vocal interaction in primates. Currently such mechanisms are poorly understood, and there are no adequate primate models available to address these issues. In this application, we will examine our research questions in a highly vocal primate, the common marmoset (Callithrix jacchus). The marmoset provides several important advantages for our studies over other primate species: a rich vocal repertoire and a high reproductive rate while in captivity. In the proposed research, we will examine two fundamental questions concerning auditory-vocal interaction in primates: 1) Does the vocal production system influence cortical processing of auditory information? 2) Is auditory input necessary to maintain normal vocal production? Specifically, we will test the hypothesis that the vocal production system modulates neural responses in the auditory cortex in primates. Furthermore, we will determine spatial distributions of neurons exhibiting vocalization-related modulated in the auditory cortex. Our preliminary data indicates that neural responses in the auditory cortex are modulated by the vocal production system, with the modulation starting prior to the vocal onset. In the second series of experiments, we will study developmental changes in marmoset vocalizations and its dependence on the auditory experience. Our hypothesis is that marmoset vocalizations undergo postnatal changes under the normal auditory environment. We will further test the hypothesis that auditory feedback is necessary for maintaining normal vocal productions. The proposed research will approach the issues related to auditory-vocal interaction in an integrated manner. Aims 1-2 and 3-4 represent intellectually linked efforts to study auditory-vocal interaction from two directions: Aims 1-2 investigate modulation of auditory processing by the vocal system, whereas Aims 3-4 investigate modulation of vocal production by the auditory system. Findings of this research will provide insight into speech production and perception mechanisms in humans and establish a parallel non-haman primate model to investigate disease-related issues in speech and hearing.

描述（由申请人提供）：拟议研究的目的是了解灵长类动物听觉-声音相互作用的生理机制。目前，人们对此类机制知之甚少，并且没有足够的灵长类动物模型来解决这些问题。在此应用中，我们将在一种高发声的灵长类动物——普通狨猴（Callithrix jacchus）中研究我们的研究问题。与其他灵长类动物相比，狨猴为我们的研究提供了几个重要的优势：丰富的发声能力和圈养时的高繁殖率。在拟议的研究中，我们将研究有关灵长类动物听觉-声音相互作用的两个基本问题：1）发声系统是否影响听觉信息的皮层处理？ 2) 听觉输入对于维持正常的发声是必要的吗？具体来说，我们将测试以下假设：发声系统调节灵长类动物听觉皮层的神经反应。此外，我们将确定听觉皮层中表现出发声相关调制的神经元的空间分布。我们的初步数据表明，听觉皮层的神经反应是由发声系统调节的，调节在发声开始之前开始。在第二个系列的实验中，我们将研究狨猴发声的发育变化及其对听觉体验的依赖性。我们的假设是，狨猴的发声在正常的听觉环境下会发生出生后的变化。我们将进一步检验听觉反馈对于维持正常发声所必需的假设。拟议的研究将以综合的方式处理与听觉-声音交互相关的问题。目标 1-2 和 3-4 代表从两个方向研究听觉-声音相互作用的智力相关努力：目标 1-2 研究发声系统对听觉处理的调制，而目标 3-4 研究听觉系统对发声的调制。这项研究的结果将深入了解人类的言语产生和感知机制，并建立一个平行的非哈曼灵长类动物模型来研究言语和听力中与疾病相关的问题。