NIMH Collaborative HIV/STD Prevention Trial (Russia)

NIMH 艾滋病毒/性病协作预防试验（俄罗斯）

基本信息

批准号：
7119995
负责人：
ANTON M SOMLAI
金额：
$ 51.49万
依托单位：
MEDICAL COLLEGE OF WISCONSIN
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-30 至 2009-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The NIMH Collaborative HIV/STD Prevention Trial is a two-arm randomized, community-level trial being conducted in five countries--China, India, Peru, Russia, and Zimbabwe. It is the first international test of a community-level prevention program and is based on the theory of diffusion of innovation utilizing Community Public Opinion Leaders (C-POLs). In this intervention model, popular opinion leaders within a high-risk population are systematically identified, recruited, trained, and engaged to communicate risk reduction messages to friends and acquaintances also in the target population. Based on a set of ethnographic studies conducted over 18 months and a series of epidemiological studies with over 9000 participants in the five countries, an assessment and the C-POL intervention have been culturally adapted, piloted and mounted in randomly-chosen venues in each country. In Russia, the study's target population is young adults who attend vocational trade schools in St. Petersburg, and the study's venues where assessment and intervention activities take place are 24 slum-like "dormitories" that house these trade school students. Epidemiological studies conducted in these venues established high rates of unprotected sex and prevalent STDs. The C-POL intervention is being carried out in the 12 Russia site dormitories randomized to the intervention condition. The intervention's efficacy in reducing self-reported behavioral risk with non-spousal partners and incident sexually transmitted diseases is being assessed based on a baseline, 12- and 24- month interviews and collection of biological specimens that are tested for STDs and HIV. After conducting the 24-month assessment, the intervention will be provided in the comparison venues. This proposal requests three years of funding to complete the randomized controlled trial in each site; the extended period is requested because of the extra time required at the initiation of the study to conduct multiple epidemiological and ethnographic studies to ensure cross-site comparability and within-site validity to all assessments, intervention, and data collection and reporting processes. The results of this trial should provide the first documentation and evaluation of the portability and adaptability of interventions cross nationally and cross-culturally and is being designed and implemented to be realistic and feasible for replication and dissemination.

描述（由申请人提供）：NIMH 艾滋病毒/性病预防协作试验是一项双组随机、社区级试验，正在五个国家（中国、印度、秘鲁、俄罗斯和津巴布韦）进行。这是社区级预防计划的首次国际测试，基于利用社区舆论领袖 (C-POL) 的创新扩散理论。在这种干预模式中，系统地识别、招募、培训高风险人群中的舆论领袖，并让其参与向目标人群中的朋友和熟人传达降低风险的信息。基于在 18 个月内进行的一系列人种学研究以及对五个国家 9000 多名参与者进行的一系列流行病学研究，评估和 C-POL 干预措施已在每个国家随机选择的地点进行了文化调整、试点和实施。在俄罗斯，该研究的目标人群是在圣彼得堡就读职业职业学校的年轻人，而该研究进行评估和干预活动的场所是24个安置这些职业学校学生的贫民窟般的“宿舍”。在这些场所进行的流行病学研究表明，无保护性行为和性传播疾病的流行率很高。 C-POL 干预正在随机分配干预条件的 12 个俄罗斯站点宿舍中进行。正在根据基线、12 个月和 24 个月的访谈以及收集的性病和艾滋病毒检测生物样本来评估干预措施在减少非配偶伴侣自我报告的行为风险和性传播疾病事件方面的功效。进行24个月的评估后，将在比较场地进行干预。该提案要求三年的资金来完成每个地点的随机对照试验；请求延长期限的原因是，在研究开始时需要额外的时间来进行多项流行病学和人种学研究，以确保所有评估、干预以及数据收集和报告过程的跨地点可比性和地点内有效性。该试验的结果应为跨国家和跨文化的干预措施的可移植性和适应性提供第一份记录和评估，并且正在设计和实施，以实现复制和传播的现实和可行。