Maximizing Opportunity - HIV Prevention in Hospitalized Russian Drinkers

机会最大化——俄罗斯住院饮酒者的艾滋病毒预防

• 批准号: 7062181
• 负责人: JEFFREY H. SAMET
• 金额: $ 68.42万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7062181
• 关键词: AIDS education /prevention; Commonwealth of Independent States; HIV infections; alcoholic beverage consumption; behavior therapy; behavioral /social science research tag; clinical research; clinical trials; culture; early /brief intervention /therapy; group counseling; high risk behavior /lifestyle; hospitals; human subject; human therapy evaluation; intravenous drug abuse; longitudinal human study; patient oriented research; sex behavior; sexually transmitted diseases; AIDS education /prevention; Commonwealth of Independent States; HIV infections; alcoholic beverage consumption; behavior therapy; behavioral /social science research tag; clinical research; clinical trials; culture; early /brief intervention /therapy; group counseling; high risk behavior /lifestyle; hospitals; human subject; human therapy evaluation; intravenous drug abuse; longitudinal human study; patient oriented research; sex behavior; sexually transmitted diseases

DESCRIPTION (provided by applicant): The HIV epidemic in Russia has occurred within the past 10 years and now includes an estimated 1 million people. Russia also has one of the highest levels of per capita alcohol consumption. Thus far, the HIV epidemic in Russia has been primarily propelled by injection drug users (IDUs). However, the risk for viral transmission beyond drug users, as previously observed in other countries when this epidemic progresses, looms large. Many HIV-infected persons with alcohol problems take part in risky sex and drug related behaviors. Thus alcohol use may accelerate HIV transmission to the general population in Russia. The objective of this proposal, HERMITAGE, HIV's Evolution in Russia - Mitigating Infection Transmission and Alcoholism in a Growing Epidemic, is to test in a randomized controlled trial the effectiveness of a US HIV secondary prevention program, Healthy Relationships Intervention, among HIV-infected patients with risky drinking in a Russian infectious disease hospital. The intervention will be culturally adapted and modified to address substance use and associated risk behaviors. The study will randomize 300 HIV-infected patients with risky alcohol consumption to an adapted Healthy Relationships Intervention (HRI) or attention-control support groups. Subjects participating in the HRI will attend 5, 2-hour structured group sessions in addition to 2, 1-hour individualized sessions. Subjects participating in the attention-control group will be exposed to support groups during the same timeframe. All patients will be assessed at baseline, 6, and 12-months post- randomization. Primary outcomes are HIV sex- and drug risk behaviors, sexually transmitted diseases, and alcohol consumption. Additionally, subjects will be assessed regarding secondary outcomes including addiction severity and disclosure of HIV serostatus. We hypothesize that relative to controls, participants receiving the Healthy Relationships Intervention will reduce HIV sex- and drug risk behaviors, STDs and alcohol consumption. If the intervention is effective among HIV-infected hospitalized patients, it could be used to address other HIV infected persons in a variety of Russian settings potentially reducing the transmission of HIV by decreasing risky sex- and drug-use behaviors.

描述（由申请人提供）：俄罗斯的艾滋病毒流行发生在过去10年内，现在包括大约100万人。俄罗斯也是人均饮酒量最高的水平之一。迄今为止，俄罗斯的艾滋病毒流行主要是由注射吸毒者（IDU）推动的。但是，在这种流行病进展时在其他国家 /地区先前观察到的那样，毒品使用者超越吸毒者的风险。许多患有酒精问题的艾滋病毒感染者参与了与性行为和毒品有关的行为。因此，饮酒可能会加速艾滋病毒向俄罗斯普通人群的传播。该提案，冬宫，艾滋病毒在俄罗斯的进化的目的 - 减轻流行病的感染传播和酒精中毒，是在一项随机对照试验中测试美国艾滋病毒二级预防计划，健康关系干预，在俄罗斯感染性疾病医院危险饮酒的患者中，美国艾滋病毒二级预防计划，健康关系干预。该干预措施将在文化上进行调整和修改，以解决药物使用和相关的风险行为。这项研究将将300例HIV感染饮酒量的患者随机，以适应健康的关系干预措施（HRI）或注意力控制支持组。参加HRI的受试者除2个小时的个性化课程外，还将参加5个小时的结构化小组会议。参与注意力控制组的受试者将在同一时间范围内暴露于支持组。所有患者将在基线，6个月和12个月后进行评估。主要结果是艾滋病毒性和药物风险行为，性传播疾病和饮酒。此外，将对受试者进行有关继发结果的评估，包括成瘾严重程度和HIV血清披露。我们假设相对于对照组，接受健康关系干预的参与者将降低HIV性别和药物风险行为，性病和饮酒。如果干预措施在感染HIV的住院患者中有效，则可以用来解决其他各种俄罗斯环境中的艾滋病毒感染者，从而通过降低风险的性和药物使用行为来减少艾滋病毒的传播。