Administrative Core

行政核心

• 批准号: 10683766
• 负责人: JEFFREY H. SAMET
• 金额: $ 16.57万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10683766
• 关键词: Acceleration; Accounting; Address; Affect; Aftercare; Alcohol consumption; Alcohols; Automobile Driving; Biometry; Bone Density; CD4 Lymphocyte Count; Cause of Death; Cessation of life; Collaborations; Communicable Diseases; Communication; Complex; Data; Data Management Resources; Disease; Ensure; Epidemiology; Fostering; Future; Goals; HIV; HIV Infections; HIV/AIDS; Heavy Drinking; Infectious Agent; Internal Medicine; International; International Aspects; Intervention; Knowledge; Leadership; Location; Lung diseases; Medicine; Mentors; Morbidity - disease rate; NIH Office of AIDS Research; Persons; Preventive treatment; Principal Investigator; Pulmonary Tuberculosis; Pulmonology; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Risk Reduction; Role; Russia; Sampling; Smoking; Statistical Data Interpretation; Training; Tuberculosis; Uganda; United States; Zinc; active method; addiction; alcohol consequences; alcohol intervention; alcohol research; alcohol risk; career; co-infection; cohort; comorbidity; data management; data sharing; experience; frailty; inflammatory marker; innovation; mortality; multidisciplinary; next generation; repository; smoking intervention; success; synergism; therapy development; tuberculosis treatment

Modified Project Summary/Abstract Section Tuberculosis (TB) is the leading cause of death from a single infectious agent worldwide, and accounts for a third of the total number of deaths caused by HIV/AIDS. Understanding the role of alcohol in new TB infection, occurrence of active TB disease, and lung disease after TB treatment in the context of HIV infection is vital to reducing the risks of TB morbidity and mortality among PLWH. The theme of the International URBAN Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Center is to understand the impact of alcohol on the spectrum of TB infection among PLWH. The International URBAN ARCH Center will continue to build on its experience in establishing and maintaining cohorts of PLWH in Uganda and will evaluate research questions uniquely addressable in this location. This global research is aligned with the NIH Office of AIDS Research’s highest priorities for HIV and HIV-related research (i.e., addressing HIV-associated comorbidities, coinfections, and complications). The Administrative (Admin) Core will provide the organizational framework for the International URBAN ARCH Center and will facilitate synergy among the Center’s 4 components: 1) Admin Core; 2) Biostatistics and Data Management (BDM) Core; 3) Research Project 1, TRAC study; and 4) Research Project 2, PTLD study. The Admin Core will be responsible for day-to-day management and functioning of the Center with the goal of ensuring that the scientific and programmatic activities of the Center are integrated and carried out with high quality and timeliness. The Admin Core will accomplish the following Specific Aims: 1) Promote a collaborative, synergistic approach to research goals; 2) Facilitate communication, integration, and collaboration between all Center components; 3) Coordinate access to resources including the International URBAN ARCH Center data and sample repository; 4) Assess and foster components’ progress and quality to maximize the scientific impact of the Center; 5) Encourage the sharing of data with investigators within the Center and beyond; and 6) Develop future leadership of the Center and the next generation of HIV/alcohol researchers. Under the leadership of the Admin Core and with its expert facilitation and research management, the International URBAN ARCH Center will generate new generalizable knowledge about the complex relationship between TB, HIV, and alcohol use in order to accelerate the future development of interventions that can reduce alcohol’s impact on TB-related morbidity and mortality among PLWH. The success of the International URBAN ARCH Center is critically dependent on the Admin Core’s scientific and administrative leadership to ensure that all components function optimally and synergistically.

修改的项目摘要/摘要部分 结核病（TB）是全世界单一传染毒剂的主要死亡原因，占艾滋病毒/艾滋病造成的死亡总数的三分之一。了解酒精在新的结核病感染中的作用，活性结核病的发生以及在HIV感染背景下结核病治疗后肺部疾病的作用对于降低PLWH中结核病发病率和死亡率的风险至关重要。国际艾滋病毒/艾滋病（Urban Arch）中心国际城市酒精研究合作的主题是了解酒精对PLWH中结核病感染的影响。国际城市拱门中心将继续建立在乌干达建立和维护PLWH的经验的基础上，并将在此地点评估研究问题。这项全球研究与NIH艾滋病研究办公室对HIV和HIV相关研究的最高优先事项（即解决与HIV相关的合并症，共同感染和并发症）的最高优先事项。行政（管理）核心将为国际城市拱门中心提供组织框架，并将促进该中心4个组件之间的协同作用：1）管理员核心； 2）生物统计学和数据管理（BDM）核心； 3）研究项目1，TRAC研究； 4）研究项目2，PTLD研究。管理员核心将负责该中心的日常管理和运作，以确保该中心的科学和程序化活动以高质量和及时的方式整合和进行。管理员核心将实现以下特定目标：1）促进一种协作，协同的研究目标； 2）促进所有中心组件之间的沟通，集成和协作； 3）协调对资源的访问，包括国际城市拱门中心数据和样本存储库； 4）评估和培养组件的进度和质量，以最大程度地发挥中心的科学影响； 5）鼓励与中心内及以后的调查人员共享数据； 6）发展中心的未来领导和下一代艾滋病毒/酒精研究人员。在管理员核心及其专家设施和研究管理的领导下，国际城市拱门中心将产生有关结核病，艾滋病毒和酒精使用之间复杂关系的新知识，以加速未来的干预措施，以减少酒精对TB相关的发病率和PLWH中与TB相关的发病率的影响。国际城市拱门中心的成功在很大程度上取决于管理员核心的科学和行政领导，以确保所有组件在最佳和协同方面发挥作用。