Maternal Lifestyle Study Phase 4

孕产妇生活方式研究第四阶段

• 批准号: 7274643
• 负责人: Henrietta S. Bada
• 金额: $ 66.71万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-19 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7274643
• 关键词: Cannabis; alcoholism /alcohol abuse; behavioral /social science research tag; child behavior disorders; child physical development; child psychology; clinical research; clinical trials; cocaine; cooperative study; data collection methodology /evaluation; early experience; embryo /fetus toxicology; gender difference; high risk behavior /lifestyle; human subject; interview; longitudinal human study; maternal behavior; mental health epidemiology; middle childhood (6-11); opiate alkaloid; patient oriented research; prenatal stress; psychological tests; racial /ethnic difference; socioenvironment; statistics /biometry; substance abuse related disorder; tobacco abuse

DESCRIPTION (provided by applicant): Prenatal substance exposure continues to be a major public health problem that affects millions of children and places enormous financial and social burdens on society. The Maternal Lifestyle Study (MLS) is an interagency collaboration involving the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the Administration on Children, Youth and Families, and the Center for Substance Abuse Treatment. MLS is being conducted in four University sites: Miami, Tennessee at Memphis, Wayne State, and Brown; and it is the largest clinical prospective longitudinal study to date of prenatal drug exposure and child outcome. The follow-up cohort includes 658 exposed and 730 comparison children who have been studied through 7 years of age with 71% retention. This application is to continue the follow-up through age 11. One aim is to study the effects of prenatal cocaine/opiate exposure on immediate child outcomes that start in infancy (e.g. attention, relationship to parent, neuromotor, physiologic reactivity, arousal/regulation, and medical status) as well as latent effects on domains of function that emerge later and become salient as children reach school age (e.g. cognition, antisocial behavior, substance use onset, psychopathology, neuroendocrine function, and health disorders). This includes determining the effects of heavy cocaine exposure and controlling for exposure to other drugs (alcohol, marijuana, and tobacco), medical (e.g. physical growth) and environmental factors, gender, minority status, and study site. The second aim is to study a broader conceptualization of the consequences of maternal drug use that includes determining how drug effects, and the effects of the postnatal environment combine to affect child outcome, including specific aspects of the environment unique to the drug culture. As a major longitudinal study, MLS is important to the field of developmental science by contributing to our understanding of developmental processes in normal and at-risk children. MLS will also contribute to the field by addressing health indicators related to Healthy People 2010. Understanding the consequences of prenatal cocaine exposure and risky environments is crucial for treatment and public policy.

描述（由申请人提供）：产前药物的暴露仍然是一个主要的公共卫生问题，影响了数百万儿童和社会上巨大的财务和社会负担。孕产妇的生活方式研究（MLS）是涉及国家儿童健康与人类发展研究所，美国国家药物滥用研究所，儿童，青年和家庭管理局以及药物滥用治疗中心的一项机构间合作。 MLS正在四个大学地点进行：迈阿密，田纳西州的孟菲斯，韦恩州和布朗；它是产前药物暴露和儿童结局迄今为止最大的临床前瞻性纵向研究。后续队列包括658个暴露和730个比较儿童，他们在7岁时接受了研究，保留率为71％。 This application is to continue the follow-up through age 11. One aim is to study the effects of prenatal cocaine/opiate exposure on immediate child outcomes that start in infancy (e.g. attention, relationship to parent, neuromotor, physiologic reactivity, arousal/regulation, and medical status) as well as latent effects on domains of function that emerge later and become salient as children reach school age (e.g. cognition, antisocial behavior,药物使用发作，心理病理学，神经内分泌功能和健康障碍）。这包括确定大量可卡因暴露的影响以及控制其他药物（酒精，大麻和烟草），医疗（例如身体生长）和环境因素，性别，少数族裔状况和研究地点的影响。第二个目的是研究对产妇使用药物的后果的更广泛的概念化，其中包括确定药物的影响以及产后环境的影响结合起来影响儿童结局，包括吸毒培养所特有的环境的特定方面。作为一项重大的纵向研究，MLS对我们对正常儿童和高危儿童的发育过程的理解做出贡献，对发展科学领域很重要。 MLS还将通过解决与健康人有关的健康指标2010的贡献。了解产前可卡因暴露和危险环境的后果对于治疗和公共政策至关重要。