Maternal Lifestyle Study Phase 5

孕产妇生活方式研究第五阶段

• 批准号: 7102901
• 负责人: Henrietta S. Bada
• 金额: $ 57.13万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-19 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7102901
• 关键词: Adolescence; Adolescent; Adult; Affect; Age; Age-Years; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Barker Hypothesis; Behavior; Behavioral; Birth; Birth Order; Birth Weight; Blood Pressure; Blood Vessels; Child; Childhood; Clinical; Clinical Research; Cocaine; Cognitive deficits; Collaborations; Condition; Development; Disease; Drug Exposure; Drug abuse; Dysmorphology; Emotional; Emotions; Environment; Environmental Risk Factor; Exposure to; Family; Fetal Cocaine Exposure; Fetal Growth; Gender; Goals; Growth; Home environment; Hypertension; Institutes; Intake; Lead; Life; Life Style; Long-Term Effects; Longitudinal Studies; Marijuana; Mediator of activation protein; Medical; Metabolic Diseases; Minority; Modeling; National Institute of Child Health and Human Development; Nutritional; Obesity; Opiates; Outcome; Parenting behavior; Parents; Participant; Pathway interactions; Performance; Pharmaceutical Preparations; Phase; Physical activity; Physiological; Placement; Population; Pregnancy; Pregnancy in Adolescence; Protocols documentation; Psychopathology; Psychosocial Factor; Public Health; Public Policy; Publishing; Purpose; Range; Rate; Research; Research Personnel; Risk; Risk-Taking; Role; Schools; Sexual Maturation; Sexually Transmitted Diseases; Site; Smoking; Societies; Sodium; Substance abuse problem; Tennessee; Teratology; Testing; Tobacco; U-Series Cooperative Agreements; Universities; Violence; Work; Youth; addiction; anti social; base; caregiving; cohort; design; drug exposure in utero; early onset substance use; fetal; fetal drug exposure; follow-up; high risk behavior; in utero; nervous system disorder; obesity risk; parity; peer; prenatal; programs; prospective; psychologic; response; size; social; therapy development

DESCRIPTION (provided by applicant): Prenatal substance exposure continues to be a major public health problem that affects millions of children and places enormous financial and social burdens on society. Little is known about the effects of prenatal cocaine exposure on psychological, developmental, medical or physical outcomes in children entering adolescence. The Maternal Lifestyle Study (MLS) is an interagency collaboration involving the National Institute of Child Health and Human Development and the National Institute on Drug Abuse. MLS is being conducted in four academic centers: The University of Miami, University of Tennessee at Memphis, Wayne State University and Brown University. MLS is the largest clinical prospective longitudinal study to date of prenatal drug exposure and child outcome. The follow-up cohort includes 658 exposed and 730 comparison children who have been studied through 9 years of age with 75% retention. The MLS study involves a unique population given its multi-site component, racial diversity, and extensive long-term follow up. One aim is to determine if prenatal cocaine or other prenatal drug exposure results in adverse psychological and developmental outcomes at 12-15 years. These outcomes include substance use (early substance use onset, smoking, alcohol consumption and substance abuse and addiction), academic and cognitive deficits (e.g., poor school performance), physiological reactivity, antisocial behavior (e.g. delinquency), psychopathology, risk taking behavior (e.g., adolescent pregnancy, sexually transmitted diseases). The role of protective factors such as positive parenting and peer relationships will also be investigated. A second aim is to determine the effects of prenatal cocaine exposure on physical and medical outcomes at 12-15 years. These outcomes include physical growth and medical illness, including hypertension, obesity and metabolic disorder, which may have their origins in fetal life, and may be related the impact of drug exposure on fetal growth. Additional outcomes include structural teratogenic effects (dysmorphology), and neurological disorders. In addition to being a study of prenatal cocaine exposure, MLS is also a study of children growing up in adverse conditions, providing information on development in typically developing children and children at risk. A thorough understanding of the consequences of prenatal cocaine exposure and associated maternal lifestyles is necessary to the development of treatment and public policy initiatives.

描述（由申请人提供）：产前药物的暴露仍然是一个主要的公共卫生问题，影响了数百万儿童和社会上巨大的财务和社会负担。关于产前可卡因暴露对进入青春期的儿童心理，发育，医学或身体结局的影响知之甚少。孕产妇的生活方式研究（MLS）是涉及国家儿童健康与人类发展研究所和美国国家药物滥用研究所的机构间合作。 MLS正在四个学术中心进行：迈阿密大学，田纳西大学孟菲斯大学，韦恩州立大学和布朗大学。 MLS是产前药物暴露和儿童结局迄今为止最大的临床前瞻性纵向研究。后续队列包括658个暴露和730个比较儿童，他们在9岁时接受了研究，保留率为75％。 MLS研究涉及独特的人群，鉴于其多站点的成分，种族多样性和广泛的长期随访。一个目的是确定产前可卡因或其他产前药物暴露在12 - 15年时会导致心理和发育效果不良。这些结果包括药物使用（早期吸烟，吸烟，饮酒以及药物滥用和成瘾），学术和认知缺陷（例如，学校表现不佳），生理反应性，反社会行为（例如，差异），心理病理学，心理病理学，风险采取行为（例如，青少年怀孕，性交疾病）。保护因素（例如积极的育儿和同伴关系）的作用也将得到研究。第二个目的是确定产前可卡因暴露对12 - 15年的身体和医疗结果的影响。这些结果包括身体生长和医学疾病，包括高血压，肥胖和代谢障碍，它们可能起源于胎儿生活，并且可能与药物暴露对胎儿生长的影响有关。其他结果包括结构性致畸作用（畸形）和神经系统疾病。除了研究产前可卡因的研究外，MLS还研究了在不良条件下成长的儿童，提供有关典型发育型的儿童和儿童发育的信息。对产前可卡因暴露和相关的孕产妇生活方式的后果有透彻的理解对于制定治疗和公共政策倡议是必要的。