Exercise Training Inflammatory Risk Factors Disability

运动训练 炎症危险因素 残疾

• 批准号: 7142298
• 负责人: Barbara J Nicklas
• 金额: $ 50.34万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7142298
• 关键词: C reactive protein; aging; behavioral /social science research tag; biomarker; body composition; clinical research; clinical trials; cooperative study; cytokine; disease /disorder prevention /control; exercise; frail elderly; functional ability; health education; human data; human old age (65+); human therapy evaluation; human tissue; inflammation; interleukin 6; muscle strength; physical fitness; physical therapy; sarcopenia; statistics /biometry

DESCRIPTION (provided by applicant): Inflammation is an underlying risk factor for aging-related physical disability; therefore, interventions that reduce inflammation in the elderly may be beneficial for the delay or treatment of loss of physical function. Data from observational studies and small, uncontrolled intervention studies suggest that physical activity may be beneficial for the treatment of chronic inflammation, but there are no data from a large, long-term, randomized, controlled exercise trial to confirm this potential benefit of exercise training. We propose to conduct an ancillary study to the on-going Lifestyle Interventions and Independence for Elders (LIFE) study, which is a four-site, single-blind randomized, controlled clinical trial in 424 elderly men and women at risk for physical disability. Our primary aim is to measure plasma concentrations of a panel of inflammatory biomarkers in fasting blood samples collected from LIFE participants at baseline, and at 6-mos and 12-mos following randomization to the interventions to test two primary hypotheses that: 1) compared to a non-exercise health education intervention, a 12-month exercise training intervention will decrease concentrations of inflammatory biomarkers (specifically CRP and IL-6) in elderly men and women at high risk for physical disability, and 2) 12-mo changes in measures of physical function (400m walk time, 4m walking speed, and chair rise time) will be inversely related to changes in the biomarkers. With completion of 180 persons per group, we will have at least 80% power to detect a 36% change in CRP, and a 20% change in IL-6, as a result of the LIFE exercise training intervention. We also propose to conduct statistical analyses to test the following secondary hypotheses: 1) the effects of the exercise intervention on inflammatory biomarkers will be independent of changes in body fat mass in a subset of LIFE participants with measures of body composition, 2) baseline measures of physical function will be related to a summary inflammation status variable derived through factor analysis of the panel of inflammatory biomarkers, and 3) the exercise intervention will reduce this summary inflammatory status variable compared to the no-exercise intervention. The results of this study will provide new knowledge regarding the effects of exercise training on several indicators of chronic inflammation and will yield valuable empirical data about which individual or combination of inflammatory markers are better predictors of poor physical function in the elderly.

描述（由申请人提供）：炎症是与衰老相关的身体残疾的潜在危险因素；因此，减少老年人炎症的干预措施可能有益于延迟或治疗身体机能丧失。来自观察性研究和小型，不受控制的干预研究的数据表明，体育活动可能对治疗慢性炎症有益，但是没有来自大型，长期，随机，对照运动试验的数据，可以证实这一潜在的运动训练益处。我们建议对持续的生活方式干预措施进行辅助研究和长辈研究的独立性（Life）研究，这是一项四个位置，单盲随机，对照临床试验，424名男性和女性有身体残疾风险。 Our primary aim is to measure plasma concentrations of a panel of inflammatory biomarkers in fasting blood samples collected from LIFE participants at baseline, and at 6-mos and 12-mos following randomization to the interventions to test two primary hypotheses that: 1) compared to a non-exercise health education intervention, a 12-month exercise training intervention will decrease concentrations of inflammatory biomarkers (specifically CRP and IL-6) in elderly men和有身体残疾的高风险的妇女，以及2）身体机能度量的12-MO变化（400m步行时间，4m步行速度和椅子上升时间）将与生物标志物的变化成反比。随着每组180人的完成，由于生活训练干预措施，我们至少有80％的能力来检测CRP变化36％的变化，而IL-6的变化为20％。我们还建议进行统计分析以测试以下次要假设：1）运动干预对炎症生物标志物的影响将独立于生命参与者的体内人体脂肪量的变化，并以身体组成的衡量标准，2）基线的基线测量值，通过列出炎症的基线，将其列出的生物分析降低。与无运动干预相比，炎症状态变量。这项研究的结果将提供有关运动训练对多种慢性炎症指标的影响的新知识，并将产生有价值的经验数据，涉及哪种炎症标记的个人或组合更好地预测了老年人身体机能不佳的因素。