AGE-RELATED DIFFERENCES IN ENERGY EXPENDITURE IN RESPONSE TO ACUTE EXERCISE

剧烈运动时的能量消耗与年龄相关的差异

• 批准号: 7951393
• 负责人: Barbara J Nicklas
• 金额: $ 0.29万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951393
• 关键词: Acute; Age; Aging; Basal metabolic rate; Body Composition; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Dual-Energy X-Ray Absorptiometry; Energy Intake; Energy Metabolism; Exercise; Expenditure; Food; Funding; Grant; Hormones; Hour; Indirect Calorimetry; Individual; Institution; Leptin; Measures; Physical activity; Pilot Projects; Records; Recruitment Activity; Research; Research Personnel; Resources; Source; Thyroid Hormones; United States National Institutes of Health; Weight; Woman; age effect; age group; age related; men; middle age; response; Acute; Age; Aging; Basal metabolic rate; Body Composition; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Dual-Energy X-Ray Absorptiometry; Energy Intake; Energy Metabolism; Exercise; Expenditure; Food; Funding; Grant; Hormones; Hour; Indirect Calorimetry; Individual; Institution; Leptin; Measures; Physical activity; Pilot Projects; Records; Recruitment Activity; Research; Research Personnel; Resources; Source; Thyroid Hormones; United States National Institutes of Health; Weight; Woman; age effect; age group; age related; men; middle age; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding changes in energy expenditure (EE) with aging is important in determining how to maintain a healthy weight at old age. The purpose of this proposed pilot study is to determine whether changes in EE in response to acute exercise are influenced by age in healthy, normal weight men and women. We hypothesize that a single 45-minute session of moderate-intensity exercise will result in a larger decline in spontaneous physical activity (SPA) and a smaller increase in resting metabolic rate (RMR) in older compared to middle-aged and younger individuals. We will also determine whether changes in EE in response to acute exercise are related to changes in regulatory hormones, including leptin and thyroid hormones. Five (5) men and 5 women will be recruited into one of three age groups: young, middle-aged, and old. SPA, RMR, and hormone levels will be measured before, immediately after and 24 hours after the acute exercise bout. SPA will be measured using a RT3 accelerometer and RMR will be measured using indirect calorimetry. As potential covariates, caloric intake will be analyzed using 1- and 4-day food records and body composition will be determined using DXA. Pre-exercise, post-exercise, and change values will be compared between age groups, after adjusting for confounding factors. The results from this study will begin to clarify the effects of age on changes in EE in response to exercise.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 了解随着衰老的衰老的理解变化（EE）对于确定如何在老年保持健康体重很重要。这项拟议的试点研究的目的是确定EE对急性运动的变化是否受健康，正常体重男性和女性年龄的影响。我们假设与中年和年轻人相比，年龄较大的45分钟中等强度运动会导致自发体育锻炼（SPA）的下降更大，而老年人的静息代谢率（RMR）较小。我们还将确定EE对急性运动的变化是否与调节激素的变化有关，包括瘦素和甲状腺激素。五（5）个男性和5名妇女将被招募为三个年龄段之一：年轻，中年和老年。水疗，RMR和激素水平将在急性锻炼后立即测量，并在24小时后测量。将使用RT3加速度计测量水疗中心，并将使用间接热量法测量RMR。作为潜在的协变量，将使用1天和4天的食物记录分析热量摄入，并使用DXA确定身体成分。调整了混杂因素后，将在年龄组之间比较运动前，运动后和变化值。这项研究的结果将开始阐明年龄对运动的变化的影响。