Intimate Partner Violence and Inflammatory Processes

亲密伴侣暴力和炎症过程

• 批准号: 7094376
• 负责人: TAMARA L. NEWTON
• 金额: $ 18.08万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7094376
• 关键词: C reactive protein; aggression; behavioral /social science research tag; biomarker; chronic disease /disorder; clinical research; disease /disorder proneness /risk; divorce /separation; domestic violence; dyadic interaction; female; human subject; inflammation; interleukin 6; interview; postmenopause; posttraumatic stress disorder; psychological aspect of aging; psychological stressor; psychoneuroimmunology; psychosocial separation; sex partner; spouse abuse; women' s health

DESCRIPTION (provided by applicant): This study will test associations between prior exposure to adult intimate partner violence (IPV) and inflammatory markers and processes that have been implicated in a variety of conditions associated with aging (e.g., cardiovascular diseases, cognitive decline). It is proposed that IPV can have long-standing consequences for inflammatory processes, particularly via the pathway of intrusive re-experiencing (e.g., recurrent, unwanted memories of prior stressful events, and physiological reactions to events reminders). Aim 1 is to establish the relationship between prior exposure to adult IPV and inflammatory markers and processes. Aim 2 is to examine how severity of IPV and severity of intrusive re-experiencing interactively contribute to inflammatory markers and processes. These aims will be examined in a cross-sectional study of two groups of healthy women who are newly postmenopausal; (1) women who are divorced/separated from violent marriages or heterosexual cohabiting relationships (n = 67), and (2) a comparison group of women divorced/separated from non-violent marriages/heterosexual cohabiting relationships (n = 33). The latter group will serve as a control for the stress of divorce/separation. Women will have blood drawn for assessment of basal concentrations of the acute-phase protein high-sensitivity C-reactive protein and the proinflammatory cytokine interleukin-6. lnterleukin-6 production by peripheral blood mononuclear cells in response to in vitro immunological challenge will also be assessed. All women will be interviewed to assess history of victimization, including IPV, and posttraumatic stress symptoms including intrusive re-experiencing. Recent research reveals that older adults' health status is associated with potentially traumatic events experienced decades earlier in adulthood. IPV is endorsed by 25% of adult women in the United States, is a risk factor for posttraumatic stress disorder, and has been associated with prevalence of chronic diseases in several cross-sectional studies. If the proposed hypotheses are supported, they will suggest a plausible basis for linkages among IPV, posttraumatic stress symptoms, and inflammatory conditions associated with aging. One long-term implication would be that evidence-based behavioral interventions that effectively treat posttraumatic stress disorder may also reduce this disorder's contribution to women's risk for developing conditions associated with aging.

描述（由申请人提供）：本研究将测试事先接触成人亲密伴侣暴力（IPV）与炎症标志物和过程之间的关联，这些标志和过程与与衰老有关的各种疾病（例如心血管疾病，认知能力下降）涉及的各种疾病。有人提出，IPV可能会对炎症过程产生长期的后果，尤其是通过侵入性重新体验的途径（例如，对先前的压力事件的反复，不必要的记忆以及对事件提醒的生理反应）。目的1是建立事先接触成人IPV与炎症标记和过程之间的关系。目的2是检查IPV的严重程度以及侵入性重新体验的严重程度如何互动有助于炎症标记和过程。这些目标将在对绝经后新的两组健康妇女的横断面研究中进行检查。 （1）与暴力婚姻或异性同性恋关系离婚/分离的妇女（n = 67），以及（2）与非暴力婚姻/异性恋同居关系的妇女比较组（n = 33）。后一组将作为离婚/分离压力的控制。妇女将抽血，以评估急性期蛋白质高敏性C反应蛋白和促炎性细胞因子白介素6的基础浓度。还将评估外周血单核细胞产生的Lnterleukin-6对体外免疫学挑战的产生。所有妇女将接受采访，以评估包括IPV在内的受害历史以及创伤后的压力症状，包括侵入性重新经历。最近的研究表明，老年人的健康状况与成年后几十年前经历的可能创伤事件有关。 IPV在美国的25％的成年妇女认可，是创伤后应激障碍的危险因素，在几项横断面研究中与慢性疾病的患病率有关。如果支持所提出的假设，它们将为IPV之间的联系，创伤后应激症状和与衰老相关的炎症疾病提出合理的基础。长期影响是，有效治疗创伤后应激障碍的基于证据的行为干预措施也可能会减少该疾病对妇女发展与衰老相关状况的风险的贡献。