Dynamic Magnetic Resonance Imaging of Bone Tumors

骨肿瘤的动态磁共振成像

• 批准号: 7085463
• 负责人: JASON Arthur KOUTCHER
• 金额: $ 36.99万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7085463
• 关键词: Ewing' s tumor; behavioral /social science research tag; bioimaging /biomedical imaging; biomarker; bone imaging /visualization /scanning; bone neoplasms; clinical research; data collection methodology /evaluation; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; histopathology; human subject; human therapy evaluation; magnetic resonance imaging; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer surgery; noninvasive diagnosis; osteosarcoma; outcomes research; patient care management; patient care planning; preoperative state; prognosis; sarcoma; Ewing' s tumor; behavioral /social science research tag; bioimaging /biomedical imaging; biomarker; bone imaging /visualization /scanning; bone neoplasms; clinical research; data collection methodology /evaluation; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; histopathology; human subject; human therapy evaluation; magnetic resonance imaging; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer surgery; noninvasive diagnosis; osteosarcoma; outcomes research; patient care management; patient care planning; preoperative state; prognosis; sarcoma

DESCRIPTION (provided by applicant): Primary bone tumors are the third most frequent tumors of adolescents and young adults. Osteogenic sarcomas (OS) (35% of all primary bone sarcomas) and Ewing's sarcoma are the most and second most common bone tumors. The most accurate prognostic indicator is percent tumor necrosis post neoadjuvant chemotherapy, as estimated by an experienced pathologist post surgery. A pre-surgical estimate of tumor necrosis and an early or a priori marker of response are necessary to further advance treatment in these diseases. The goals of this proposal are to: 1A) To determine if dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) can reliably predict percent necrosis. 1B) Evaluate the hypothesis that in patients with Ewing's or OS, the a priori or early (18-24 days) DCE-MRI study predicts percent necrosis measured by pathological analysis performed at surgery and disease free survival 2) Compare the predictive value of using "semi-quantitative" analyses vs. quantitative models. We will also compare the effects of measuring the input function directly in order to determine if more complex modeling schemes are more accurate in predicting tumor response. The value of the 2 site exchange model analysis and the effect of relaxing the assumption that equilibrium transcytolemmal water transport remains in the "fast exchange limit" and replacing this concept with a more rigorous two site exchange (2SX) model, and its effect on evaluating the DCE-MRI data relationship to tumor necrosis and response will also be analyzed. This will determine if the method of analysis impacts accuracy of predicting tumor response or percent necrosis. 3) Determine if the DCE-MRI results are superior and independent markers of tumor response compared to current clinical markers. We will compare the prognostic value of the DCE-MRI studies vs. molecular and clinical prognosticators. This project will determine the potential of DCE-MRI to predict tumor necrosis and as an a priori or early marker of tumor response to neoadjuvant therapy. If successful, it will provide a tool to predict failure/response to chemotherapy, resulting in patient specific treatment which will likely enhance outcome.

描述（由申请人提供）： 原发性骨肿瘤是青少年和年轻人的第三大常见肿瘤。成骨肉瘤（OS）（所有原发性骨肉瘤的35％）和尤因的肉瘤是最常见的骨肿瘤。如经验丰富的病理学家手术后估计，新辅助化疗后新辅助化疗后最准确的预后指标是肿瘤坏死的百分比。需要对肿瘤坏死的手术前估计值和早期或先验的反应标记，以进一步提高这些疾病的治疗。该提案的目标是：1a）确定动态对比度是否增强磁共振成像（DCE-MRI）可以可靠地预测坏死百分比。 1B）评估以下假设：在Ewing或OS的患者中，先验或早期（18-24天）DCE-MRI研究预测，通过在手术和无疾病生存下进行的病理分析测量的坏死百分比2）比较使用“半定量”分析的预测价值。我们还将比较直接测量输入函数的效果，以确定更复杂的建模方案在预测肿瘤反应方面是否更准确。 2个现场交换模型分析的价值以及放宽平衡的跨环甲菌水传输的假设保留在“快速交换极限”中，并用更严格的两个站点交换（2SX）模型替换了这一概念，并且它对评估DCE-MRI数据与Tumor Necrisosis和响应的影响也将得到分析。这将确定分析方法是否影响预测肿瘤反应或坏死百分比的准确性。 3）确定与当前临床标记相比，DCE-MRI结果是否是肿瘤反应的优越和独立的标记。我们将比较DCE-MRI研究与分子和临床预后剂的预后价值。该项目将确定DCE-MRI预测肿瘤坏死的潜力，并确定肿瘤对新辅助治疗的先验或早期标志物。如果成功，它将提供一种预测化学疗法失败/反应的工具，从而导致患者特定的治疗方法，这可能会增强结果。