Core--Pulmonary Toxicology

核心--肺毒理学

• 批准号: 6867267
• 负责人: GUNTER OBERDORSTER
• 金额: $ 5.96万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6867267
• 关键词: air pollution; biomedical facility; environmental contamination; environmental exposure; environmental health; environmental toxicology; inflammation; oxidative stress; pulmonary respiration; respiratory disorder; respiratory toxin

Description (provided by applicant): The overall aim of this core is to evaluate mechanisms of oxidative injury, inflammation and repair in both the respiratory and cardiovascular systems caused by environmental and occupational agents. This aim has been a central focus for the core since the 1940?s when Rochester first began investigation into the pulmonary toxicology of airborne particulates. Focus today continues not only on airborne particulates, but also on oxidant gases, endotoxin, siloxanes, zinc oxide and ionizing radiation. Experimental approaches range from basic cellular and molecular methods to animal and clinical human studies. The core studies the impact of inhaled agents in asthma, COPD, fibrosis and lung cancer. Factors that modulate the toxicological effects of inhaled agents, such as age and underlying disease, are also studied. A new approach that has evolved over the last 5 years is the focus on systemic effects of inhaled agents, in particular effects on the cardiovascular system. Nearly 50% of the 181 publications cited since the last renewal are joint authored by members of the core, speaking to the intense collaborative effort underway. The studies carried out by core members result in publications in strong, high-impact scientific journals (AJP Lung, AJRCCM, Environ Health Perspectives, J Immunol, Inhalation Toxicol). All members are now housed under one roof with the construction of a new research building, enhancing the collaborative effort.

描述（由申请人提供）：该核心的总体目的是评估由环境和职业药物引起的呼吸道和心血管系统中氧化损伤，炎症和修复的机制。自1940年以来，罗切斯特（Rochester）首次开始研究空气中颗粒的肺毒理学时，这个目标一直是核心的核心重点。今天的重点不仅继续放在空气中的微粒上，而且还在氧化气体，内毒素，硅氧烷，氧化锌和电离辐射上。实验方法范围从基本的细胞和分子方法到动物和临床人类研究。核心研究吸入药物在哮喘，COPD，纤维化和肺癌中的影响。还研究了调节吸入药物（例如年龄和潜在疾病）的毒理学作用的因素。在过去5年中，一种新的方法是对吸入剂的全身作用的重点，特别是对心血管系统的影响。自上次续签以来的181个出版物中，近50％是由核心成员共同撰写的，并与正在进行的紧张合作努力进行了交流。核心成员进行的研究导致出版物中强烈的，高影响力的科学期刊（AJP肺，AJRCCM，Environ Health Perspectives，J Immunol，Antaination Toxicol）。现在，所有成员都被安置在一个屋顶下，建造了一座新的研究大楼，从而增强了协作的工作。