CORE--CARDIORESPIRATORY SUSCEPTIBILITY

核心--心肺敏感性

• 批准号: 6577781
• 负责人: JANE O KOENIG
• 金额: $ 7.35万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6577781
• 关键词: age difference; air pollution; antioxidants; biomedical facility; cardiovascular disorder; environmental contamination; environmental exposure; environmental health; environmental toxicology; genetic susceptibility; laboratory mouse; pollution related respiratory disorder

The 0-5 year Respiratory Susceptibility Core has been renamed the Cardiorespiratory Susceptibility Core to reflect a changing emphasis of the research group, undoubtedly influenced by the Particulate Air Pollution and Health proposal, recently submitted and reportedly to be funded by the EPA, which includes almost all core researchers (8 senior members, 8 associate members). The goal of the latter $8.3M EPA proposal is to study the effects of particulates on susceptible populations, the focus being on both the respiratory and cardiovascular systems. The EPA Group will be organized into three resource cores: Health, Exposure, and Biostatistics, and several research cores emphasizing studies of particulate exposure, dosimetry, and modeling, with strong epidemiological components. Some toxicological components will use transgenic mouse strains and an innovative risk assessment/management component. Some emphasis is given to the EPA proposal because it will strongly impact the overall research resources and expertise available to the Cardiorespiratory Core. The Core itself includes research activities focused on antioxidant modulations of ozone airway responses, polymorphism studies relevant to allergic asthma, mouse asthma models, cell models to study effects of ozone on inflammatory mediator and possible free radical related pathways, transgenic mouse models of cardiovascular disease, and epidemiologic studies of air pollution health effects. To a large degree the research activities of the group are determined by the successes of the group members in the grants arena.

0 - 5年的呼吸敏感性核心已重命名 心肺易感性核心反映了不断变化的重点 研究小组无疑受到颗粒空气污染的影响 和健康提案，最近提交并据报道由 EPA，几乎包括所有核心研究人员（8位高级成员，8位同事 成员）。后者的830万美元EPA提案的目标是研究效果 易感人群的颗粒物的重点是 呼吸道和心血管系统。 EPA组将组织成 三个资源核心：健康，暴露和生物统计学，有几个 研究核心强调颗粒物暴露，剂量法和 建模，具有强大的流行病学成分。一些毒理学 组件将使用转基因小鼠菌株和创新的风险 评估/管理组件。 EPA提案给予了一些重点 因为它将强烈影响总体研究资源和专业知识 可用于心肺核心。 核心本身包括针对抗氧化剂的研究活动 臭氧气道反应的调节，多态性研究与 过敏性哮喘，小鼠哮喘模型，研究臭氧对臭氧作用的细胞模型 炎症介质和可能的自由基相关途径，转基因 心血管疾病的小鼠模型和空气流行病学研究 污染健康影响。在很大程度上 小组取决于赠款中的小组成员的成功 竞技场。