CORE--CARDIORESPIRATORY SUSCEPTIBILITY

核心--心肺敏感性

• 批准号: 6301472
• 负责人: JANE O KOENIG
• 金额: $ 11.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301472
• 关键词: age difference; air pollution; antioxidants; biomedical facility; cardiovascular disorder; environmental contamination; environmental exposure; environmental health; environmental toxicology; genetic susceptibility; laboratory mouse; pollution related respiratory disorder

Description: The 0-5 year Respiratory Susceptibility Core has been renamed the Cardiorespiratory Susceptibility Core to reflect a changing emphasis on the research group, undoubtedly influenced by the Particulate Air Pollution and Health proposal, recently submitted and reported to be funded by the EPA, which includes almost all core researchers (8 senior members, 8 associate members). The goal of the latter $8.3M EPA proposal is to study the effects of particulates on susceptible populations, the focus being on both the respiratory and cardiovascular systems. The EPA Group will be organized into three resource cores: Health, Exposure, and Biostatistics, and several research cores emphasizing studies of particulate exposure, dosimetry, and research cores emphasizing studies of particular exposure, dosimetry, and modeling, with strong epidemiological components. Some toxicological components will use transgenic mouse strains and an innovative risk assessment/management component. Some emphasis is given to the EPA proposal because it will strongly impact the overall research resources and expertise available to the Cardiorespiratory Core. The Core itself includes research activities focused on antioxidant modulations of ozone airway responses, polymorphism studies relevant to allergic asthma, mouse asthma models, cell models to study effects of ozone on inflammatory mediator and possible free radical related pathways, transgenic mouse models of cardiovascular disease, and epidemiologic studies of air pollution health effects. To a large degree the research activities of the group are determined by the successes of the group members in the grants arena.

描述：0 - 5年的呼吸易感性核心已重命名为心肺易感性核心，以反映对研究小组的重视不断变化，无疑受到颗粒空气污染和健康建议的影响，最近提交并报告由EPA资助，其中包括几乎所有核心​​研究人员（包括8名高级成员，8位员工）。后者830万美元的EPA提案的目的是研究颗粒物对易感人群的影响，重点是呼吸道和心血管系统。 EPA组将分为三个资源核心：健康，暴露和生物统计学，以及一些研究核心强调颗粒暴露，剂量测定和研究核心的研究，强调对特定暴露，剂量测定和建模的研究，具有强大的流行性分量。一些毒理学成分将使用转基因小鼠菌株和创新的风险评估/管理组件。 EPA提案给予了一些重点，因为它将强烈影响心肺核心可用的总体研究资源和专业知识。核心本身包括针对臭氧气道反应的抗氧化剂调节，与过敏性哮喘相关的多态性研究，小鼠哮喘模型，研究臭氧对炎症介质的影响以及可能自由基相关途径的影响，心血管疾病模型的转基因小鼠模型，以及空气污染健康研究的细胞基因小鼠模型。在很大程度上，小组的研究活动取决于赠款领域的小组成员的成功。