Gynecologic Oncology Group- HUMAN SPECIMEN BANK

妇科肿瘤组 - 人类样本库

• 批准号: 6930268
• 负责人: Philip J. DiSaia
• 金额: $ 57万
• 依托单位: GYNECOLOGIC ONCOLOGY GROUP
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6930268
• 关键词: clinical research; clinical trials; cooperative study; female; gene expression; gynecology; human subject; microarray technology; oncology; ovary neoplasms; proteomics; tissue resource /registry; women' s health

DESCRIPTION (provided by applicant): The Gynecologic Oncology Group (GOG) is the premier clinical trial research program investigating new therapeutic approaches in the management of gynecologic malignancies. This multidisciplinary, multimodal Group comprises over 200 participating university and large community hospitals with over 3000 investigator-participants in all specialties of cancer study. An important component of the program is the Committee on Experimental Medicine (CEM) composed of basic and clinical scientists with active studies of cancer translational research. The CEM has oversight over the GOG Tissue Bank through its' Tissue Utilization Subcommittee (TUS). Over the decade of its existence, the GOG Tissue Bank has received and processed tissue from more than 6,100 patients and served over 52,000 specimens to approximately 146 investigators. Over one-half (54%) of all bank registrations are ovarian epithelial malignancies and 52% of these are on a therapeutic protocol. For the general GOG banking protocol (GOG-136), 95% of cases have paired normal tissue (22% with white blood cell pellets), an important adjunct for molecular studies. Nearly 100 institutions submit specimens each year. The number of tissues distributed represents improved access by investigators to the GOG Tissue Bank via NCI web sites and networking of investigators via the Cooperative Human Tissue Network. The GOG Tissue Bank has accounted for 146 scientific papers over the last 10 years, with an increased emphasis on gene expression microarray and proteomics studies within the last two years. The GOG Tissue Bank is poised and flexible to monitor and modify its tissue procurement and distribution technologies to meet changing investigator needs. The Specific Aims of this project are: 1. Management of specimens from patients enrolled in NCI-sponsored clinical treatment trials to maintain an accurate and effective bank of tumor and normal tissues with associated clinical, epidemiologic and protected health information. 2. Promotion of studies by qualified investigators with supervision by the GOG Committee on Experimental Medicine as well as disease-specific committees of the GOG. 3. Expansion of innovative technologies facilitating molecular research and increased investigator participation in clinical research trials. 4. Maintenance of strict control procedures to ensure high quality capture, processing and distribution of specimens. 5. Participation in the development of scientific papers and presentations describing the results of this valuable tissue and data resource.

描述（由申请人提供）： 妇科肿瘤小组 (GOG) 是研究妇科恶性肿瘤治疗新治疗方法的首要临床试验研究项目。这个多学科、多模式的小组由 200 多家参与的大学和大型社区医院组成，拥有癌症研究所有专业的 3000 多名研究者参与者。该计划的一个重要组成部分是实验医学委员会（CEM），该委员会由积极研究癌症转化研究的基础和临床科学家组成。 CEM 通过其组织利用小组委员会 (TUS) 对 GOG 组织库进行监督。 GOG 组织库成立十年来，已接收并处理了 6,100 多名患者的组织，并向大约 146 名研究人员提供了 52,000 多个样本。超过一半 (54%) 的银行登记是卵巢上皮恶性肿瘤，其中 52% 正在接受治疗方案。对于一般 GOG 库方案 (GOG-136)，95% 的病例具有配对的正常组织（22% 与白细胞沉淀），这是分子研究的重要辅助手段。每年有近100家机构提交标本。分发的组织数量意味着研究人员可以通过 NCI 网站访问 GOG 组织库，并通过合作人体组织网络建立研究人员网络。 GOG 组织库在过去 10 年中收录了 146 篇科学论文，并且在过去两年中更加重视基因表达微阵列和蛋白质组学研究。 GOG 组织库随时准备灵活地监控和修改其组织采购和分配技术，以满足不断变化的研究者需求。 该项目的具体目标是： 1. 管理参加 NCI 赞助的临床治疗试验的患者标本，以维护准确有效的肿瘤和正常组织库以及相关的临床、流行病学和受保护的健康信息。 2. 在 GOG 实验医学委员会以及 GOG 特定疾病委员会的监督下，促进合格研究人员的研究。 3. 扩大创新技术，促进分子研究并增加研究者对临床研究试验的参与。 4. 维持严格的控制程序，确保标本的高质量采集、处理和分发。 5. 参与撰写描述这一宝贵组织和数据资源结果的科学论文和演示文稿。