Gynecologic Oncology Group- HUMAN SPECIMEN BANK

妇科肿瘤组 - 人类样本库

• 批准号: 7283080
• 负责人: Philip J. DiSaia
• 金额: $ 57.34万
• 依托单位: GYNECOLOGIC ONCOLOGY GROUP
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7283080
• 关键词: Accounting; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Community Hospitals; Cooperative Human Tissue Network; Data; Development; Disease; Enrollment; Ensure; Epithelial; Gene Expression; Gynecologic; Gynecologic Oncology Group; Health; Improve Access; Institution; Internet; Leukocytes; Maintenance; Malignant Neoplasms; Medicine; Molecular; Monitor; Normal tissue morphology; Numbers; Ovarian; Paper; Participant; Patients; Procedures; Process; Proteomics; Protocols documentation; Qualifying; Research; Research Personnel; Resources; Scientist; Site; Specimen; Supervision; Technology; Therapeutic; Tissue Banks; Tissue Procurements; Tissues; Translational Research; Tumor Bank; Universities; innovative technologies; medical specialties; multidisciplinary; novel therapeutics; programs; tissue processing; treatment trial

DESCRIPTION (provided by applicant): The Gynecologic Oncology Group (GOG) is the premier clinical trial research program investigating new therapeutic approaches in the management of gynecologic malignancies. This multidisciplinary, multimodal Group comprises over 200 participating university and large community hospitals with over 3000 investigator-participants in all specialties of cancer study. An important component of the program is the Committee on Experimental Medicine (CEM) composed of basic and clinical scientists with active studies of cancer translational research. The CEM has oversight over the GOG Tissue Bank through its' Tissue Utilization Subcommittee (TUS). Over the decade of its existence, the GOG Tissue Bank has received and processed tissue from more than 6,100 patients and served over 52,000 specimens to approximately 146 investigators. Over one-half (54%) of all bank registrations are ovarian epithelial malignancies and 52% of these are on a therapeutic protocol. For the general GOG banking protocol (GOG-136), 95% of cases have paired normal tissue (22% with white blood cell pellets), an important adjunct for molecular studies. Nearly 100 institutions submit specimens each year. The number of tissues distributed represents improved access by investigators to the GOG Tissue Bank via NCI web sites and networking of investigators via the Cooperative Human Tissue Network. The GOG Tissue Bank has accounted for 146 scientific papers over the last 10 years, with an increased emphasis on gene expression microarray and proteomics studies within the last two years. The GOG Tissue Bank is poised and flexible to monitor and modify its tissue procurement and distribution technologies to meet changing investigator needs. The Specific Aims of this project are: 1. Management of specimens from patients enrolled in NCI-sponsored clinical treatment trials to maintain an accurate and effective bank of tumor and normal tissues with associated clinical, epidemiologic and protected health information. 2. Promotion of studies by qualified investigators with supervision by the GOG Committee on Experimental Medicine as well as disease-specific committees of the GOG. 3. Expansion of innovative technologies facilitating molecular research and increased investigator participation in clinical research trials. 4. Maintenance of strict control procedures to ensure high quality capture, processing and distribution of specimens. 5. Participation in the development of scientific papers and presentations describing the results of this valuable tissue and data resource.

描述（由申请人提供）： 妇科肿瘤学小组（GOG）是一项主要的临床试验研究计划，研究了妇科恶性肿瘤管理的新治疗方法。这个多学科的多模式小组包括200多个参与大学的大学和大型社区医院，其中包括3000多名癌症研究专业的研究员参与者。该计划的一个重要组成部分是实验医学委员会（CEM），由基本和临床科学家组成，并对癌症转化研究进行了积极研究。 CEM通过其组织使用小组委员会（TUS）对GOG组织库进行监督。在其存在的十年中，GOG组织库已从6,100多名患者接收并处理组织，并为大约146名研究人员提供了52,000多个标本。所有银行注册的一半以上（54％）是卵巢上皮恶性肿瘤，其中52％是根据治疗方案。对于一般的GOG银行协议（GOG-136），有95％的病例具有正常组织（22％与白细胞颗粒），这是分子研究的重要辅助。每年将近100个机构提交标本。分布的组织数量代表了研究人员通过NCI网站和通过合作的人体组织网络的网络进行了对GOG组织库的访问。在过去的十年中，GOG组织库在过去两年中占了146篇科学论文，对基因表达微阵列和蛋白质组学研究的重视程度越来越多。 GOG组织库有望且灵活，可以监视和修改其组织采购和分配技术，以满足不断变化的研究者需求。 该项目的具体目的是： 1。从NCI赞助的临床治疗试验中招募的患者的标本管理，以维持具有相关临床，流行病学和受保护的健康信息的准确有效的肿瘤和正常组织。 2。在GOG实验医学委员会的监督下以及GOG的疾病特定委员会的监督下促进研究人员的研究。 3。促进分子研究并增加了研究者参与临床研究试验的创新技术的扩展。 4。维护严格的控制程序，以确保标本的高质量捕获，处理和分布。 5。参与科学论文和演讲的开发，描述了这种有价值的组织和数据资源的结果。