Gynecologic Oncology Group Specimen Banking

妇科肿瘤组样本库

• 批准号: 8531386
• 负责人: Philip J. DiSaia
• 金额: $ 75万
• 依托单位: GYNECOLOGIC ONCOLOGY GROUP
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531386
• 关键词: Canada; Cervical; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Cooperative Human Tissue Network; Data; Data Collection; Development; Discipline; Disease; Drug or chemical Tissue Distribution; Enrollment; Ensure; Epidemiology; Grant; Gynecologic; Gynecologic Oncology Group; Health; Human; Improve Access; Institution; Link; Maintenance; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Medical Research; Medicine; Microscopy; Molecular; Molecular Profiling; Monitor; Normal tissue morphology; Nucleic Acids; Ovarian; Paper; Pathology; Patients; Peritoneal; Procedures; Process; Qualifying; Research; Research Personnel; Resources; Specimen; Specimen Handling; Supervision; Technology; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Tumor Tissue; United States; Work; base; data exchange; digital; innovative technologies; insight; meetings; multidisciplinary; novel therapeutic intervention; novel therapeutics; programs; treatment trial; virtual; web site

DESCRIPTION (provided by applicant): The Gynecologic Oncology Group (GOG) is a premier multidisciplinary, multimodal clinical trial research program investigating new therapeutic approaches in the management of gynecologic malignancies. The GOG Tissue Bank, through the Tissue Utilization Subcommittee of the Committee on Experimental Medicine, is an integral part of this program. Since 2003, the GOG Tissue Bank has received and processed specimens from close to 46,000 patients enrolled at over 250 institutions. The Bank also distributed over 81,000 specimens to 215 investigators, resulting in 122 scientific papers. This is reflective of improved access by investigators to the GOG Tissue Bank via NCI web sites and networking of investigators via the Cooperative Human Tissue Network. The GOG Tissue Bank monitors and modifies its tissue procurement and distribution technologies to meet changing investigator needs. This is evidenced by the introduction of tissue microarray and virtual microscopy technologies during the last grant cycle, Our Specific Aims are; 1. To extend the spectrum of molecular research in gynecologic cancer via expanded procurement of not only ovarian, but also cervical, uterine, primary peritoneal and rare gynecologic malignancies. 2. To enhance biospecimen data collection and exchange with the Statistical Data Center and all participating GOG disciplines and committees to advance translational research and high-impact discoveries. 3. To extend the spectrum of virtual microscopy and digital pathology for gynecologic cancer via expanded participation, use, and functionality of the technology 4. To continue to expand tissue-based technologies including nucleic acid extractions and tissue microarrays (TMAs) to facilitate molecular research. 5. To harmonize with other Cooperative Group Banks through NCI Group Banking Committee initiatives to simplify investigators' access to biospecimens and associated data.

描述（由申请人提供）：妇科肿瘤学组（GOG）是一项主要的多学科，多模式临床试验研究计划，研究了妇科恶性肿瘤管理的新治疗方法。 GOG组织库通过实验医学委员会的组织利用小组委员会是该计划不可或缺的一部分。自2003年以来，GOG组织库已收到并处理了来自250多家机构的近46,000名患者的标本。该银行还向215名调查人员分发了超过81,000个标本，产生了122篇科学论文。这反映了研究人员通过NCI网站和通过合作人类组织网络的网络进行了改善的访问GOG组织。 GOG组织库监视并修改其组织采购和分配技术，以满足不断变化的研究者需求。在上一个赠款周期中引入组织微阵列和虚拟显微镜技术可以证明这一点，我们的具体目的是： 1。通过扩大卵巢的采购，还扩大宫颈，子宫，原发性腹膜和罕见的妇科恶性肿瘤，扩大了妇科癌的分子研究范围。 2。为了增强与统计数据中心以及所有参与的GOG学科和委员会的生物循环数据收集和交流，以提高转化研究和高影响力的发现。 3。通过扩大技术的参与，使用和功能4。继续扩展基于组织的技术，包括核酸提取物和组织微阵列（TMA）（TMA），以扩大妇科癌症的虚拟显微镜和数字病理学的范围，以促进分子研究。 5。通过NCI集团银行委员会倡议与其他合作集团银行协调，以简化研究人员获得生物测量和相关数据的访问。