International Epi Databases to Evaluate AIDS (IEDEA) in central Africa (Region 9)

中部非洲（第 9 区）艾滋病评估国际 Epi 数据库 (IEDEA)

• 批准号: 7252566
• 负责人: Tyler D Hartwell
• 金额: $ 124.22万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7252566
• 关键词: AIDS Treatment Research; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Adverse effects; Affect; Africa; Africa South of the Sahara; African; Anti-Retroviral Agents; Antiretroviral drug resistance; Appearance; Applications Grants; Award; Behavioral; Belgium; Brazil; Burundi; CD4 Lymphocyte Count; Cameroon; Capital; Caring; Case Study; Cause of Death; Centers for Disease Control and Prevention (U.S.); Central Africa; Central African Republic; Certification; Cessation of life; Chad; Characteristics; Child; Cities; Classification; Clinic; Clinical; Clinical Research; Cohort Analysis; Communicable Diseases; Competence; Complex; Condition; Congo; Consensus; Consent; Contracts; Country; Coupled; Data; Data Analyses; Data Collection; Data Coordinating Center; Databases; Decentralization; Democratic Republic of the Congo; Developed Countries; Developing Countries; Development; Diagnosis; Disease; Distant; Dose; Drug resistance; Drug usage; Electronics; Emergency Situation; Epidemic; Epidemiologist; Equatorial Guinea; Equipment; Europe; European Union; Evaluation; Event; Exhibits; Extrasensory Perception; Faculty; Failure; Female of child bearing age; Fostering; France; Frequencies; Funding; Future; Gabon; General Population; Genetic Recombination; Genetic Variation; Goals; Gold; Government Officials; Grant; Gray unit of radiation dose; HIV; HIV Infections; HIV drug resistance; HIV-1; Head; Health; Health Personnel; Health Services Accessibility; Healthcare; Human Resources; In Vitro; Individual; Infection; Institutes; Institution; International; International AIDS; Interruption; Investigation; Investments; Knowledge; Laboratories; Letters; Light; Link; Malaria; Malnutrition; Maps; Measures; Medical; Medical Records; Medical Surveillance; Methods; Minority; Modeling; Molecular Diagnosis; Monitor; Morbidity - disease rate; N(delta)-acetylornithine, -isomer; N-dodecanoylglutamic acid, -isomer, sodium salt; Names; North America; North Carolina; Nucleotides; Numbers; Opportunistic Infections; Orphan; Outcome; Paris, France; Patient Noncompliance; Patients; Pharmaceutical Preparations; Pharmacotherapy; Pharmacy facility; Play; Policies; Population; Predisposition; Prevalence; Principal Investigator; Process; Provider; Proxy; Psychological reinforcement; Public Health; Public Health Schools; Qualitative Research; Quality of life; Rate; Recombinants; Recording of previous events; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resistance; Resources; Reverse Transcriptase Inhibitors; Risk; Role; Running; Rwanda; Salvage Therapy; Sampling; Sao Tome and Principe; Sensitivity and Specificity; Sentinel; Serological; Sorting - Cell Movement; Southern Africa; Specialist; Specific qualifier value; Standards of Weights and Measures; System; Technology; Testing; Therapeutic Studies; Thinking; Time; Training; Treatment Factor; Treatment Failure; Treatment Protocols; Treatment outcome; Tropical Medicine; Tuberculosis; United States; United States National Institutes of Health; Universities; Viral; Viral Load result; Virus; Visit; Vital Statistics; Western Europe; Work; alpha-difluoromethyl-DOPA, -isomer; alpha-methylornithine dihydrochloride, -isomer; antiretroviral therapy; base; care systems; cohort; cost effective; cost effectiveness; desire; drug efficacy; drug resistant virus; experience; fitness; follow-up; forging; inclusion criteria; insight; medical schools; medication compliance; member; mortality; pandemic disease; prescription document; prescription procedure; professor; programs; recombinant virus; research study; response; scale up; success; tool; transmission process; treatment center; trend

DESCRIPTION (provided by applicant): This application proposes to establish an International Epidemiologic Database to Evaluate AIDS (IEDEA) Regional Center to harmonize HIV data and data collection in Region 9 - Central Africa. A Regional Data Center, backstopped by Research Triangle International (RTI), Research Triangle Park, North Carolina will be located in Kinshasa, Democratic Republic of Congo (DRC) at the University of North Carolina/DRC UNC/DRC) HIV/AIDS Clinical Research Unit at the Kinshasa School of Public Health. This multi-step research and capacity building process will occur through regional expansion/reinforcement of the existing partnership between the UNC's School of Public Health, the Kinshasa School of Public Health, RTI and the DR Congo's Programme National Multisectoriel de Lutte centre le SIDA (PNMLS). Additional international collaborators are: (1) Institute of Tropical Medicine in Antwerp, Belgium; (2) Institut National d'Etudes Demographiques Research Unites Mortalite Sante Epidemiologie et Population and Developpement, Paris, France; (3) Institut de Recherche pour le Developpement and Department of International Health, University of Montpellier, Montpellier France. Region 9 collaborators from Burundi, Cameroon, Central African Republic, Congo/Brazzaville, Democratic Republic of Congo, and Rwanda include HIV/AIDS clinicians /care providers, representatives of national HIV programs, and faculty from national medical schools. Our regional consortium has 20,200 patients currently on ARV's in a database and are following an additional 46,000 HIV-infected individuals who are not yet eligible to receive ART treatment. Harmonization of data across our region is the initial goal. When this is in place, our proposed research agenda will include: (1) Identify new region-appropriate models of HIV care and systems for monitoring its efficacy; (2) Monitor sentinel populations for ARV resistance; (3) Determine the role the high rate of genetic diversity for HIV seen in this region plays on ARV resistance.

描述（由申请人提供）：本申请提议建立一个国际流行病学数据库，以评估IADS（IEDEA）区域中心，以协调中非地区9-地区的HIV数据和数据收集。北卡罗来纳州研究三角研究三角国际研究中心（RTI）将位于北卡罗来纳州民主共和国（DRC）北卡罗来纳州/刚果民主共和国UNC/drc）HIV/AIDS HIV/AIDS临床研究单位的区域数据中心。这项多步研究和能力建设过程将通过区域扩展/加强UNC的公共卫生学院，金​​沙萨公共卫生学院，RTI和刚果博士的计划国家多人多欧赛尔·德·卢特中心（PNMLS）之间的现有合作伙伴关系。其他国际合作者是：（1）比利时安特卫普的热带医学研究所； （2）国家人口统计学研究所研究将凡士林Sante Peremiologie et and Gutess and Devaptimpement，法国巴黎，法国； （3）法国蒙彼利埃大学蒙彼利埃大学蒙彼利埃大学的pourche pourche pour pour pour pourche pourche pourche。 Bundi，喀麦隆，中非共和国，刚果/布拉萨维，刚果民主共和国和卢旺达的9区合作者包括艾滋病毒/艾滋病临床医生/护理提供者，国家艾滋病毒计划的代表以及来自国家医学院的教职员工。我们的区域财团目前在数据库中的ARV中有20200名患者，并遵循尚未有资格接受ART治疗的46,000名HIV感染者。最初的目标是整个地区的数据协调。到位后，我们提出的研究议程将包括：（1）确定适合艾滋病毒护理和系统的新模型，以监测其功效； （2）监视前哨种群的ARV电阻； （3）确定在该区域中观察到的HIV的高遗传多样性对ARV抗性的作用。