International Epi Databases to Evaluate AIDS (IEDEA) in central Africa (Region 9)

中部非洲（第 9 区）艾滋病评估国际 Epi 数据库 (IEDEA)

• 批准号: 7118350
• 负责人: Tyler D Hartwell
• 金额: $ 103.2万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7118350
• 关键词: AIDS; Africa; clinical research; communication; experience; health; information systems; schools

DESCRIPTION (provided by applicant): This application proposes to establish an International Epidemiologic Database to Evaluate AIDS (IEDEA) Regional Center to harmonize HIV data and data collection in Region 9 - Central Africa. A Regional Data Center, backstopped by Research Triangle International (RTI), Research Triangle Park, North Carolina will be located in Kinshasa, Democratic Republic of Congo (DRC) at the University of North Carolina/DRC UNC/DRC) HIV/AIDS Clinical Research Unit at the Kinshasa School of Public Health. This multi-step research and capacity building process will occur through regional expansion/reinforcement of the existing partnership between the UNC's School of Public Health, the Kinshasa School of Public Health, RTI and the DR Congo's Programme National Multisectoriel de Lutte centre le SIDA (PNMLS). Additional international collaborators are: (1) Institute of Tropical Medicine in Antwerp, Belgium; (2) Institut National d'Etudes Demographiques Research Unites Mortalite Sante Epidemiologie et Population and Developpement, Paris, France; (3) Institut de Recherche pour le Developpement and Department of International Health, University of Montpellier, Montpellier France. Region 9 collaborators from Burundi, Cameroon, Central African Republic, Congo/Brazzaville, Democratic Republic of Congo, and Rwanda include HIV/AIDS clinicians /care providers, representatives of national HIV programs, and faculty from national medical schools. Our regional consortium has 20,200 patients currently on ARV's in a database and are following an additional 46,000 HIV-infected individuals who are not yet eligible to receive ART treatment. Harmonization of data across our region is the initial goal. When this is in place, our proposed research agenda will include: (1) Identify new region-appropriate models of HIV care and systems for monitoring its efficacy; (2) Monitor sentinel populations for ARV resistance; (3) Determine the role the high rate of genetic diversity for HIV seen in this region plays on ARV resistance.

描述（由申请人提供）：本申请提议建立一个评估艾滋病的国际流行病学数据库 (IEDEA) 区域中心，以协调第 9 区 - 中非的艾滋病毒数据和数据收集。由北卡罗莱纳州三角研究园国际三角研究 (RTI) 支持的区域数据中心将位于刚果民主共和国 (DRC) 金沙萨的北卡罗莱纳大学/刚果民主共和国大学 (UNC/DRC) 艾滋病毒/艾滋病临床研究金沙萨公共卫生学院单位。这一多步骤的研究和能力建设过程将通过区域扩展/加强北卡罗来纳大学公共卫生学院、金沙萨公共卫生学院、RTI 和刚果民主共和国国家多部门 de Lutte 中心 le SIDA 项目 (PNMLS) 之间的现有伙伴关系进行区域扩展/加强。 ）。其他国际合作者包括： (1) 比利时安特卫普热带医学研究所； (2) 法国巴黎国家人口统计学研究所，Mortalite Sante Epidemiologie et Population and Developmentement； (3) 蒙彼利埃大学发展研究所和国际卫生系，法国蒙彼利埃。来自布隆迪、喀麦隆、中非共和国、刚果/布拉柴维尔、刚果民主共和国和卢旺达的第 9 区合作者包括艾滋病毒/艾滋病临床医生/护理人员、国家艾滋病毒项目的代表以及国家医学院的教职人员。我们的区域联盟的数据库中目前有 20,200 名接受 ARV 治疗的患者，并且正在追踪另外 46,000 名尚不符合接受 ART 治疗资格的 HIV 感染者。协调整个地区的数据是最初的目标。当这一点到位时，我们提出的研究议程将包括：（1）确定适合地区的新的艾滋病毒护理模式和监测其功效的系统； (2) 监测哨点人群的抗逆转录病毒药物耐药性； (3) 确定该地区艾滋病毒遗传多样性的高比率对抗逆转录病毒药物耐药性的作用。