Longitudinal Analysis of Health-Related Quality of Life in an Aging Population

老龄化人口健康相关生活质量的纵向分析

• 批准号: 7013793
• 负责人: MARK S. KAPLAN
• 金额: $ 19.85万
• 依托单位: PORTLAND STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7013793
• 关键词: Canada; United States; aging; behavioral /social science research tag; data collection methodology /evaluation; data quality /integrity; disease /disorder proneness /risk; functional ability; geographic difference; health economics; health science research analysis /evaluation; health surveys; human data; human morbidity; human mortality; interview; longitudinal human study; mathematical model; quality of life; statistics /biometry

DESCRIPTION (provided by applicant): Health-related quality of life measures are important outcome indicators in clinical trials of healthcare interventions and in evaluations of public health programs. There has been growing interest in utility (preference-based) measures of health-related quality of life. A utility measure provides a single summary score reflecting the value of a health state where 0.00 represents dead and 1.00 is perfect health. These measures permit the integration of mortality and morbidity to summarize population health and are crucial in economic evaluations. However, there are few (if any) long-term studies examining changes in health utility over time in large populations. Consequently, there is little prospective information about aging and utility. Moreover, it is unclear if changes over time in utility are similar to or different from changes over time in widely available measures such as self-rated health. In addition, there are uncertainties about the changes over time in health domains (e.g., pain) that contribute to health utility. Also, and importantly, the impacts on utility of major risk factors for mortality (such as smoking or obesity) have yet to be examined longitudinally. The proposed project will address these issues using ten years of follow-up data on quality of life measured by the Health Utilities Index Mark 3 (HUI3). In the last decade, HUI3 has come into widespread use as a multidimensional measure of health-related quality of life. HUI3 assesses eight domains: vision, hearing, speech, ambulation, dexterity, emotion, cognition, and pain. The index uses population-based preferences to combine the several domains into a single-dimensional weighted average consistent with the requirements for a utility measure. The proposed longitudinal secondary data analysis project will (a) examine change over time in the HUI3 (and its components) across the life course, (b) conduct similar examinations of change over time in self-rated health, (c) investigate predictors of change over time in HUI3, and (d) compare HUI3 scores between Canada and the United States. The project will utilize the Canadian National Population Health Survey which contains ten years of follow-up interviews including HUI3 measures every other year and the 2003 Joint Canada-United States Survey of Health. The project will lay the foundations for future work in which medical and public health interventions (such as risk factor reduction programs) are evaluated according to their impact on health-related quality of life.

描述（由申请人提供）：与健康相关的生活质量措施是医疗干预和公共卫生计划评估的临床试验中的重要结果指标。人们对与健康相关的生活质量的效用（基于偏好）的量度越来越兴趣。公用事业措施提供了一个摘要得分，反映了0.00代表死亡的健康状态的价值，而1.00是完美的健康。这些措施允许将死亡率和发病率整合到总结人口健康，并且在经济评估中至关重要。但是，很少有（如果有）长期研究检查大量人群中健康公用事业的变化。因此，关于衰老和效用的前瞻性信息很少。此外，目前尚不清楚在公用事业中随着时间的推移而变化是否与广泛可用的措施（例如自我评估的健康）中的变化相似或不同。此外，关于随着时间的流逝的变化（例如，疼痛）有助于卫生公用事业的情况，存在不确定性。而且，重要的是，对死亡率主要危险因素的效用（例如吸烟或肥胖）的影响尚未纵向研究。拟议的项目将使用有关卫生公用事业指数标记3（HUI3）衡量的生活质量的十年后续数据解决这些问题。在过去的十年中，HUI3广泛用作与健康相关的生活质量的多维衡量。 HUI3评估了八个领域：视觉，听力，言语，移动，敏捷，情感，认知和痛苦。该指数使用基于人群的偏好将多个域结合到单维加权平均值中，符合公用事业措施的要求。拟议的纵向二级数据分析项目将（a）检查整个生命过程中HUI3（及其组成部分）随着时间的流逝，（b）在自我评估的健康中对随着时间的变化进行类似的变化检查，（c）研究HUI3中随时间变化的预测指标，（d）比较HUI3分数的HUI3分数。该项目将利用加拿大全国人口健康调查，其中包含每隔一年的《 HUI3措施》和2003年加拿大联合国家健康调查（HUI3措施）的十年后续访谈。该项目将根据其对健康相关生活质量的影响评估医疗和公共卫生干预措施（例如降低风险因素计划）的未来工作基础。