Investigation into the characteristics of crystal dissolution and growth through surface chemistry and mass transfer in the boundary layer

通过表面化学和边界层传质研究晶体溶解和生长的特性

• 批准号: 2746217
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2746217
• 关键词: Investigation; into; characteristics; crystal; dissolution

The performance of a drug is dependent on the bioavailability of the API (Active Pharmaceutical Ingredient). In the case of many oral drugs, this is influenced by its dissolution characteristics. Indeed, dissolution is usually tested throughout a drug's development lifetime. Currently, the Noyes-Whitney model is used in most cases, which only considers the difference in the bulk concentration and the concentration at the solid-liquid interface. This model makes several assumptions about the concentrations involved and fails to consider the surface chemistry. It would therefore be useful to make more accurate predictions about a substance's solubility based on its material characteristics to expedite the drug development process. For instance, it may help influence decisions on the dosage composition. This will require gaining a better understanding of the kinetics of dissolution on a fundamental level.Ideally, a material's dissolution characteristics would be determinable using only knowledge of its surface chemistry (including how this varies between different faces) and how its interaction with the solvent molecules. Though this may not be entirely achievable, it is still worth exploring new ways of predicting a substance's dissolution behavior.A key aspect in this research is gaining a better understanding of the face specific dissolution rates of single crystals, so that theories regarding surface energy interactions can be validated. To achieve this, it will be necessary to employ various techniques, such as Mach-Zehnder and Michelson interferometry, as well as optical microscopy to observe any changes in the crystal morphology. Additionally, it is also worth looking at differences in dissolution between different crystal structures (e.g., form I and II of Paracetamol), to determine how this may influence the overall efficacy of drug formulations.

药物的性能取决于API（活性药物成分）的生物利用度。对于许多口服药物，这受到其溶解特征的影响。实际上，通常在整个药物的发育寿命中测试溶解。目前，在大多数情况下使用Noyes-Whitney模型，这仅考虑块浓度的差异和固定液体界面处的浓度。该模型对所涉及的浓度做出了一些假设，并且未能考虑表面化学。因此，根据其材料特征来加快药物开发过程，对物质的溶解度做出更准确的预测将是有用的。例如，它可能有助于影响剂量组成的决策。这将需要在基本层面上更好地了解溶解的动力学。理想地，仅使用其表面化学知识（包括不同面之间的变化）以及其与溶剂分子的相互作用，可以确定材料的溶解特征。尽管这可能不是完全可以实现的，但仍然值得探索预测物质溶解行为的新方法。这项研究中的关键方面是对单晶的面部特定溶解速率有了更好的了解，以便可以验证有关表面能量相互作用的理论。为了实现这一目标，有必要采用各种技术，例如Mach-Zehnder和Michelson干涉法，以及光学显微镜来观察晶体形态的任何变化。此外，还值得研究不同晶体结构之间的溶解差异（例如，扑热息痛的I和II），以确定这可能如何影响药物制剂的总体功效。