Neural investigations into cooperative social interactions in marmoset dyads

狨猴二人组合作社会互动的神经研究

• 批准号: 10369856
• 负责人: Steve Wohn Chul Chang
• 金额: $ 24.64万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10369856
• 关键词: Altruism; Animal Model; Animals; Attenuated; Behavior; Behavioral; Behavioral Paradigm; Biological Models; Brain; Brain region; Breeding; Callithrix; Callithrix jacchus jacchus; Catalogs; Characteristics; Code; Complex; Cooperative Behavior; Data; Dependence; Electrodes; Electrophysiology (science); Elements; Ethology; Exhibits; Face; Functional Magnetic Resonance Imaging; Future; Head; Human; Individual; Investigation; Laboratory Animal Models; Maintenance; Mediating; Neurobiology; Neurons; Neurophysiology - biologic function; Neurosciences; Outcome; Partner in relationship; Play; Prefrontal Cortex; Primates; Probability; Process; Property; Recording of previous events; Research; Resolution; Rewards; Role; Sexual Partners; Shapes; Signal Transduction; Social Behavior; Social Functioning; Social Interaction; Time; Transgenic Organisms; base; behavioral study; deep learning; density; experimental study; field study; imaging study; innovation; interest; learning network; member; neuroimaging; neuromechanism; neurotransmission; nonhuman primate; novel strategies; programs; public health relevance; relating to nervous system; sex; social; social cognition; social cooperation; social deficits; social factors; social group; social structure; wireless

Project Summary Advanced social cognition permits cooperative and reciprocal interactions with other group members, making it possible for us and other highly social animals to capitalize on various benefits associated with prosociality. However, investigating the neural bases of cooperative interactions is quite challenging largely due to the fact that standard laboratory animal models of neuroscience do not overtly or reliably exhibit cooperative behaviors, let alone reciprocity based on altruism. Marmosets are cooperatively breeding non-human primates known for their prosociality and socially tolerant characteristics making them a model system with strong potential for use towards understanding complex social behaviors. Marmosets also provide strong promise for generating transgenic primates, and their flat cortices allow easy access to brain regions with high-density electrodes. In this exploratory R21 proposal, we will capitalize on recent advances in video-based continuous tracking of facial features and body orientations using a deep learning network to rigorously characterize cooperative interactions of marmoset dyads. Further, we will study neural activity from the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (dlPFC) – the two prefrontal regions centrally implicated in cooperation based on human functional magnetic resonance imaging studies – using wireless and high-density neural recording, allowing examinations of neural activity during naturalistic social interactions that are not accessible in traditional head- restrained electrophysiology experiments. We will apply these novel approaches in a cooperative behavioral paradigm inspired by marmoset behavioral ethology and primatology. We hypothesize that neurons in the OFC process reinforcing properties of cooperation, whereas neurons in the dlPFC strategically implement cooperation decisions. Overall, our proposal uniquely allows studying neural dynamics with precise, naturalistic, behavioral data, overcoming the difficulty of using naturalistic behaviors in experimental settings and of collecting neural data in observational field studies. The data from this R21 proposal will be critical for developing a larger research program in the future with multiple scopes and causal elements for understanding the neural mechanisms underlying cooperative social interaction.

项目摘要 高级社会认知允许合作和相互互动与其他小组成员，使其成为 对于我们和其他高度社交动物来说，可能利用与亲社会相关的各种收益。 但是，研究合作互动的神经基础很大程度上是挑战 神经科学的标准实验室动物模型不会公开或可靠地暴露于合作行为， 更不用说基于利他主义的互惠。马尔莫果正在合作繁殖以非人类的素数 他们的亲社会性和社会宽容特征使它们成为具有强大使用潜力的模型系统 要了解复杂的社会行为。摩尔果还为产生提供了强烈的希望 转基因灵长类动物及其平坦皮质可以轻松进入具有高密度电极的大脑区域。 这个探索性R21提案，我们将利用基于视频的不断跟踪面部的最新进展 使用深度学习网络的功能和身体取向，以严格地表征教练互动 果果二元组。此外，我们将研究来自轨道额皮质（OFC）和背侧的神经元活性 前额叶皮层（DLPFC） - 基于人类的合作中心实施的两个前额叶区域 功能磁共振成像研究 - 使用无线和高密度神经记录，允许 在自然主义社会互动过程中对神经活动的检查 约束电生理实验。我们将在合作行为中应用这些新颖的方法 范式受到摩尔马斯行为伦理学和灵长类学的启发。我们假设OFC中的神经元 处理合作的加强特性，而DLPFC中的神经元可以战略性地实施合作 决定。总体而言，我们的建议独特地允许以精确，自然，行为的精确研究神经动力学 数据，克服在实验环境中使用自然行为的困难和收集中性 观察现场研究中的数据。该R21提案的数据对于开发更大的研究至关重要 未来的程序具有多个范围和因果因素，以理解神经机制 基本的合作社会互动。