Prefrontal and Amygdalar Mechanisms of Live Social Gaze Interaction

实时社交凝视互动的前额叶和杏仁核机制

• 批准号: 10670053
• 负责人: Steve Wohn Chul Chang
• 金额: $ 57.05万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670053
• 关键词: Agonist; Amygdaloid structure; Area; Attention; Behavior; Behavioral; Brain; Brain region; Code; Communication; Complex; Cues; Data; Eye; Familiarity; Human; Individual; Juice; Lead; Life; Link; Macaca; Modeling; Neurons; Pattern; Personal Communication; Process; Rewards; Role; Shapes; Signal Transduction; Social Behavior; Social Environment; Social Interaction; Stimulus; Sum; Testing; directed attention; gaze; information processing; neural; neural circuit; neural correlate; neurotransmission; nonhuman primate; preference; receptor; social; social cognition; social deficits; stimulus processing

Project Summary Social interactions are marked by contingent and dynamic gaze exchanges among individuals, and these exchanges powerfully shape inter-individual communication and coordinated social behaviors. Consequentially, divergent social gaze interactions frequently lead to challenges in gathering and processing information from others and further disrupt other social cognition. An excellent use of a non-human primate model is to study neural circuits underlying contingent and dynamic social gaze, and test for their causal contributions. We have shown that interacting with a real partner leads to drastically different social gaze dynamics compared to observing the same conspecific in pictures or videos. Furthermore, using this live social gaze interaction paradigm, we have recently found robust neural correlates of social gaze interaction in the orbitofrontal cortex (OFC) and the basolateral amygdala (BLA). However, causal roles of OFC and BLA, and the OFC-BLA interplay, in regulating social gaze interaction remain unestablished. Informed by our latest data and other emerging findings from the field, we hypothesize that (1) BLA is required for preferentially directing attention to social stimuli by processing social gaze valence, whereas (2) OFC is required for regulating social gaze interaction according to social context, and that (3) the communication between OFC and BLA is required for contingent and dynamic social gaze interaction. To test this overarching hypothesis, we will first examine the functional relationship between social gaze preference and value processing in OFC and BLA neurons. We hypothesize that BLA neurons process social gaze interaction using a valence schema, whereas OFC neurons do not. Second, we will examine the necessity of OFC, BLA, and the OFC-BLA interplay in social gaze interaction by temporarily inactivating OFC or BLA, or cross-inactivating OFC and BLA. We hypothesize that BLA is necessary for preferentially directing attention to partner’s eyes and processing them, whereas OFC is necessary for social context-dependent changes in gaze dynamics linked to dominance and familiarity between pairs. We also predict that the direct communication between OFC and BLA is particularly crucial for interactive aspects of social gaze. Finally, by recording neural activity from one area while temporarily inactivating the other area, we will examine the neural representations of social gaze interaction in OFC and BLA that require functioning BLA or OFC, respectively. Results from this proposal will provide functionally informed causal contributions of the OFC-BLA circuits in real-life social gaze interaction.

项目摘要 社会互动以个人之间的偶然而动态的凝视交流为标志，这些交流 交流有力地塑造了个体间的交流和协调的社会行为。因此， 分歧的社会凝视互动经常导致从收集和处理信息的挑战 其他人，进一步破坏其他社会认知。非人类私人模型的极好使用是研究 神经回路的基础和动态的社会目光，并测试其因果关系。我们有 表明，与真实伴侣的互动会导致与 在图片或视频中观察相同的概念。此外，使用这种现场社会凝视互动 范式，我们最近发现了轨道皮质中社会凝视相互作用的强大神经相关性 （OFC）和基底外侧杏仁核（BLA）。但是，OFC和BLA的因果关系以及OFC-BLA相互作用， 在调节社会凝视的过程中，互动仍然没有建立。通过我们的最新数据和其他新兴 我们从现场的发现，我们假设（1）优先将注意力引向社会需要（1）BLA 通过处理社会凝视价来刺激，而（2）OFC是需要调节社会凝视互动所必需的 根据社会背景，（3）OFC和BLA之间的沟通是需要关注的 和动态的社会凝视互动。为了检验这个总体假设，我们将首先检查功能 OFC和BLA神经元中的社会目光偏好与价值处理之间的关系。我们假设 BLA神经元使用Valence架构处理社交目光的相互作用，而OFC神经元则没有。 其次，我们将研究OFC，BLA和OFC-BLA的必要 暂时灭活c或bla，或交叉灭活c和bla。我们假设BLA是必要的 优先将注意力引向伴侣的眼睛并处理它们，而OFC对于社交是必要的 凝视动力学的上下文依赖性变化与对之间的优势和熟悉程度相关。我们也预测 OFC和BLA之间的直接沟通对于社会目光的互动方面尤为重要。 最后，通过从一个区域记录神经活动，同时暂时失活了另一个区域，我们将检查 OFC和BLA中社会凝视相互作用的神经表示，需要运行BLA或OFC， 该提案的结果将提供功能知情的因果关系贡献 现实生活中的社会凝视互动中的电路。