Amygdala and Prefrontal Control of the Rhinal Cortices

杏仁核和鼻皮质的前额叶控制

• 批准号: 7109535
• 负责人: ELIZABETH P BAUER
• 金额: $ 4.88万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7109535
• 关键词: amygdala; arousal; behavioral /social science research tag; brain electrical activity; cats; electroencephalography; emotions; entorhinal cortex; gamma aminobutyrate; injection /infusion; memory; neural information processing; neuropharmacology; neurotransmitter antagonist; postdoctoral investigator; prefrontal lobe /cortex; single cell analysis; stereotaxic techniques

DESCRIPTION (provided by applicant): The rhinal cortices play a critical role in declarative memory and constitute the main route for impulse traffic between the hippocampus and cortex. However, physiological data suggests that the rhinal cortices are not a passive relay station; neocortical and entorhinal inputs are transmitted with a low probability. The goal of the research described here is to assess whether and how the inhibitory mechanisms that limit impulse propagation through the rhinal cortices are lifted. One possibility is that this could occur during emotionally arousing conditions, when declarative memory is generally enhanced. Both the amygdala and medial prefrontal cortex project heavily to the rhinal cortices, and both are implicated in the facilitation of memory by emotions. Both extracellular and intracellular recordings in vivo in anesthetized cats will assess the ability of the amygdala and medial prefrontal cortex to facilitate impulse transfer through the rhinal cortices.

描述（由申请人提供）：Rhinal Cortices在声明记忆中起着至关重要的作用，构成了海马和皮质之间冲动流量的主要途径。但是，生理数据表明，鼻皮层不是被动的继电器站。新皮层和内嗅输入的概率低。此处描述的研究的目的是评估是否以及如何解除限制脉冲传播的抑制性机制。一种可能性是，当声明性记忆通常增强时，这可能会在情绪引起的条件下发生。杏仁核和内侧前额叶皮层都大量投射到鼻系皮层，并且都与情绪促进记忆有关。麻醉猫中体内的细胞外和细胞内记录都将评估杏仁核和内侧前额叶皮层促进通过鼻皮层脉冲转移的脉冲转移的能力。