mGluRs and Synaptic Plasticity in the Lateral Amygdala

mGluRs 和外侧杏仁核的突触可塑性

• 批准号: 6794012
• 负责人: ELIZABETH P BAUER
• 金额: $ 1.24万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794012
• 关键词: amygdala; conditioning; electron microscopy; electrophysiology; glutamate receptor; immunocytochemistry; laboratory rat; long term potentiation; male; neural information processing; neural plasticity; predoctoral investigator; protein localization; synapses; tissue /cell preparation

Neural plasticity in the lateral nucleus of the amygdala (LA) is believed to underlie the acquisition and retention of Pavlovian fear condition. One candidate mechanism for this plasticity is associative long-term potentiation (LTP), The goal of the research described here is to assess the possible role of metabotropic glutamate receptors (mGluRs) in associative LTP in the LA. While much has been learned about the roles of mGluRs in plasticity in other regions of the brain, relatively little is known about their contribution to amygdala function and plasticity. In vitro studiers will assess the contribution of mGluRs to both the input specificity of LTP, as well as the temporal integrations of inputs to the LA. Finally, Immunohistochemical studies, combined with electron microscopy, will identify the subcellular distributions of the group I mGluRs. These studies should provide insight into the contributions of mGluRs to synaptic plasticity in the amygdala.

据信，杏仁核（LA）的外侧核中的神经可塑性是帕夫洛夫恐惧条件的获取和保留的基础。这种可塑性的一种候选机制是联想长期增强（LTP），此处描述的研究的目的是评估LA中代谢性谷氨酸受体（MGLURS）在LA中的联想LTP中的可能作用。尽管关于mglurs在大脑其他地区可塑性中的作用已经有很多了解，但对它们对杏仁核功能和可塑性的贡献相对较少。体外研究员将评估mglurs对LTP的输入特异性的贡献，以及输入对LA的时间整合。最后，与电子显微镜结合的免疫组织化学研究将鉴定I组MGLURS的亚细胞分布。这些研究应洞悉mglurs对杏仁核突触可塑性的贡献。