Childhood Neurodevelopmental and Degenerative Disease

儿童神经发育和退行性疾病

基本信息

批准号：
7091598
负责人：
IRA BERGMAN
金额：
$ 20.66万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-01 至 2008-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7091598
关键词：
Childhood Neurodevelopmental Degenerative Disease

项目摘要

DESCRIPTION (provided by applicant) Although some recognition of the unique aspects of the nervous system of the developing child clearly began in the 1800's, child neurology did not evolve as an independent intellectual and clinical discipline until the 1900's. Over this past "Decade of the Brain", this relative newcomer to both the clinic and the research laboratory has begun to bear fruit. Identification of the gene defects responsible for the spinocerebellar degenerations, muscular dystrophies, and Rett's syndrome, our new understanding of the importance of mitochondrial function for muscle and brain integrity, and ontological mapping and typing of the receptors for excitotoxic neurotransmitters are a few examples of contributions of child neurology to the body of knowledge that spans the gap between the clinic and the basic science laboratory. However, increasing emphasis on revenue generation, care for those who constitute the taxpaying and voting workforce, and repayment of medical school debt have made it increasingly difficult to attract, foster, and maintain a cadre of individuals whose interests are in the development of a translational body of knowledge and the dialogue between the laboratory bench and the clinic. It is absolutely vital that we establish and nurture venues in which to train researchers at the interface between pediatric neurology and developmental neurobiology. The present application proposes to take advantage of the high quality, interactive, and interdisciplinary faculty and environment of the University of Pittsburgh and Children's Hospital of Pittsburgh, to give clinically trained fellows the opportunity to engage in and understand clinical and/or basic neurobiology research, develop in these fellows the thinking skills and knowledge base that will allow their application of basic neurobiological principles to clinical disorders of the developing nervous system, and foster the academic careers of these fellows by providing the guidance and framework necessary for the conduct of scientifically sound, ethical, and clinically relevant research in neurobiology.

描述（由申请人提供）尽管某些认识到神经系统的独特方面成长的孩子显然始于1800年代，儿童神经病学并没有发展为直到1900年代的独立知识和临床学科。为此过去的“大脑十年”，这个诊所和诊所的相对新来者研究实验室已经开始结出果实。鉴定基因缺陷负责脊椎病变性，肌肉营养不良和 RETT综合征，我们对线粒体重要性的新理解肌肉和大脑完整性的功能，以及本体论映射和键入的功能兴奋性神经递质的受体是一些例子儿童神经病学对跨越差距的知识体体的贡献在诊所和基础科学实验室之间。但是，增加强调创收，照顾那些构成纳税的人投票劳动力和偿还医学院债务已成为越来越难以吸引，培养和维护个人干部他们的兴趣是发展知识的转化体和实验室长凳与诊所之间的对话。绝对我们建立和培养在培训研究人员的地点的至关重要小儿神经病学与发育神经生物学之间的接口。本申请建议利用高质量的优势互动和跨学科的教师和环境匹兹堡和匹兹堡儿童医院，接受临床培训研究员有机会参与和了解临床和/或基本神经生物学研究，在这些研究员中发展思维技巧和知识库将允许他们应用基本的神经生物学发育中神经系统的临床疾病的原则，并促进这些研究员的学术职业通过提供指导和框架进行科学声音，道德和临床的行为所必需的神经生物学的相关研究。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Identifying neurocognitive deficits in adolescents following concussion.

识别青少年脑震荡后的神经认知缺陷。

DOI：
10.1111/j.1553-2712.2011.01015.x
发表时间：
2011
期刊：
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
影响因子：
0
作者：
Thomas,DannyG;Collins,MichaelW;Saladino,RichardA;Frank,Virginia;Raab,Jenny;Zuckerbraun,NoelS
通讯作者：
Zuckerbraun,NoelS

Multiple sclerosis and acute disseminated encephalomyelitis diagnosed in children after long-term follow-up: comparison of presenting features.