Advanced IVUS Imaging with MUTs

使用 MUT 进行高级 IVUS 成像

• 批准号: 7018367
• 负责人: F. Levent Degertekin
• 金额: $ 48.08万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7018367
• 关键词: angiocardioultrasonography; aorta; atherosclerosis; atherosclerotic plaque; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; clinical biomedical equipment; coronary artery; disease /disorder model; heart catheterization; laboratory rabbit; microelectrodes; microprocessor /microchip; miniature biomedical equipment; silicon; technology /technique development

DESCRIPTION (provided by applicant): Intravascular ultrasound (IVUS) imaging has become an essential imaging modality for the effective diagnosis and treatment of cardiovascular diseases during the past decade due to innovative applications of piezoelectric transducer technology. The limitations of the same piezoelectric transducers have impeded the improvement of IVUS for emerging clinically important applications such as forward viewing arrays for guiding interventions, high resolution imaging of arterial structure such as vulnerable plaque, vasa vasorum and fibrous cap, and for implementation of techniques such as harmonic imaging of the arterial tissue and of the contrast agents. In this project, we plan to proceed on two parallel paths with immediate and long term impact. On one path we propose to develop low cost, low profile, broadband CMUT-based IVUS probes with 2 to 4 single chip annular arrays to generate M-mode slices of coronary arteries around 25MHz center frequency and 100% fractional bandwidth. These arrays will improve the crossing capabilities of IVUS catheters and can be potentially scanned and pulled back manually to generate images during interventions. Implementation and testing of these probes will enhance our understanding of issues related to the manufacturing of CMUT-based IVUS arrays and result in possible design improvements. In parallel with this effort, the second path aims to explore innovations in CMUT design to enable novel IVUS applications. CMUTs with dual electrode structures not only improve the pressure output for high penetration depth and tissue harmonic generation, but these transducers may simplify the probe electronics by removing the need for transmit-receive switching. Dual electrode CMUT structure coupled with mass loaded CMUT membranes opens up other possibilities. With enhanced sensitivity to selected harmonics based on these novel CMUTs, the proposed research may advance medical ultrasound imaging in general generating an impact much broader than IVUS.

描述（由申请人提供）：由于压电换能器技术的创新应用，血管内超声（IVUS）成像在过去十年中已成为有效诊断和治疗心血管疾病的重要成像方式。相同压电换能器的局限性阻碍了 IVUS 在新兴临床重要应用中的改进，例如用于指导干预的前视阵列、动脉结构（如易损斑块、血管滋养管和纤维帽）的高分辨率成像，以及用于实施诸如作为动脉组织和造影剂的谐波成像。在这个项目中，我们计划沿着两条平行的道路前进，产生即时和长期的影响。在一种方法中，我们建议开发低成本、薄型、基于宽带 CMUT 的 IVUS 探头，具有 2 至 4 个单芯片环形阵列，以生成大约 25MHz 中心频率和 100% 分数带宽的冠状动脉 M 模式切片。这些阵列将提高 IVUS 导管的交叉能力，并且可以在干预期间手动扫描和拉回以生成图像。这些探针的实施和测试将增强我们对基于 CMUT 的 IVUS 阵列制造相关问题的理解，并可能实现设计改进。与此同时，第二条路径旨在探索 CMUT 设计的创新，以实现新颖的 IVUS 应用。具有双电极结构的 CMUT 不仅可以改善高穿透深度和组织谐波生成的压力输出，而且这些传感器可以通过消除发射-接收切换的需要来简化探头电子设备。双电极 CMUT 结构与质量负载 CMUT 膜相结合开辟了其他可能性。由于基于这些新颖的 CMUT 对选定谐波的敏感性增强，拟议的研究可能会推动医学超声成像的发展，产生比 IVUS 更广泛的影响。