Pediatric Neuroscience Research Program

儿科神经科学研究计划

基本信息

批准号：
8058657
负责人：
IRA BERGMAN
金额：
$ 15.53万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-03 至 2013-06-30
项目状态：
已结题

项目摘要

Although some recognition of the unique aspects of the nervous system of the developing child clearly began in the 1800's, child neurology did not evolve as an independent intellectual and clinical discipline until the 1900's. Over this past "Decade of the Brain", this relative newcomer to both the clinic and the research laboratory has begun to bear fruit. Identification of the gene defects responsible for the spino-cerebellar degenerations, spinal muscular atrophies, and Rett's syndrome, our new understanding of the importance of mitochondrial function for muscle and brain integrity, and ontological mapping and typing of the receptors for excitotoxicneurotransmitters are a few examples of contributions ofchild neurology to the body of knowledge that spans the gap between the clinic and the basic science laboratory. However, increasing emphasis on revenue generation, care for those who constitute the taxpaying and voting workforce, and repayment of medical school debt have made it increasingly difficult to attract, foster, and maintain a cadre of individuals whose interests are in the development of a translational bodyof knowledge and the dialogue between the laboratorybench and the clinic. It is absolutely vital that we establish and nurture venues in which to train and develop researchers at the interfacebetween pediatric neurology and developmental neurobiology. The present application proposes to take advantage of the high quality, interactive, and interdisciplinary faculty and environment of the University of Pittsburgh and Children's Hospital of Pittsburgh, to give clinically trained junior faculty in Child Neurology the opportunity to engage in and understand clinical and/or basic neurobiology research, develop in these faculty the thinking skills and knowledge base that will allow their application of basic neurobiological principles to clinical disorders of the developing nervous system, and foster the academic careers of these faculty by providing the guidance and framework necessary for the conduct of scientifically sound, ethical, and clinicallyrelevant research in neurobiology, and the environment and resources necessary to initiate their successful transition from mentored to independent researchers.

尽管有些认识到发育中的孩子神经系统的独特方面显然是从1800年代开始的，儿童神经病学并没有发展为独立的智力和临床纪律直到1900年代。在过去的“大脑十年”中，这两个诊所的相对新来者研究实验室已经开始结出果实。识别负责的基因缺陷 Spino-Cerebellar变性，脊柱肌肉萎缩和RETT综合征，我们对线粒体功能对肌肉和大脑完整性以及本体论映射和兴奋性毒素神经递质的受体的键入是几个贡献的例子神经学对跨越诊所与基础科学实验室之间差距的知识体系。但是，越来越重视收入产生，照顾那些构成纳税的人和投票劳动力和偿还医学院的债务使吸引越来越困难，福斯特，并维持一群在转化体中的利益的个人干部实验室和诊所之间的知识与对话。我们绝对至关重要建立和培养在小儿之间培训和发展研究人员的场所神经病学和发育神经生物学。本应用程序建议利用高质量，互动和匹兹堡大学和儿童医院的跨学科教师和环境匹兹堡，为临床培训的儿童神经病学初级教师提供参与和了解临床和/或基本神经生物学研究，在这些教师中发展思维技能和知识库将使他们将基本神经生物学原理应用于临床疾病发展的神经系统，并通过提供指导来培养这些教师的学术职业以及在科学，道德和临床上进行科学，道德和临床研究所必需的框架神经生物学以及从事成功过渡所必需的环境和资源对独立研究人员进行指导。