Developing behavioural methods to assess pain in horses

开发评估马疼痛的行为方法

• 批准号: 2686844
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2025
• 资助国家: 英国
• 起止时间: 2025 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2686844
• 关键词: Developing; behavioural; methods; assess; pain

As of 1st July 2022, Olivia Curry commenced a new PhD project Developing behavioural methods to assess pain in horses under the Supervision of Cathy Dwyer, Juliet Duncan and Gemma Pearson.This studentshi project will look at the causes, risk factors and diagnoses associated with Equine Grass Sickness (EGS), adopting an inter-disciplinary collaborative approach. Both biological and environmental factors will be investigated, with the student having the opportunity to review all available research and using a multi-disciplinary approach, identify gaps in knowledge and undertake relevant research strands to elucidate causal agents and risk factors. Previous research has looked at individual potential causal agents and the lack of success so far in identifying a causative agent suggests it may be multifactorial.The main strands of this research project will include:- Developing a relevant and novel in vitro system comprising 3D gut enteroid cultures from horses to enable the study of the early host-pathogen interactions following challenge of the in vitro cultures with some of the leading candidate causal agents that may be involved in equine grass sickness. - Investigating the use of saliva as a non-invasive test in horses to detect host immune responses to a range of candidate antigens from potential causal agents that may play a role in inducing equine grass sickness. - Samples for the project will be collected in longitudinal studies in selected areas where grass sickness has been prevalent in recent years.- Establishment of a national biobank and database, including questionnaire development, collaborating with vets, horse owners and researchers, to collect biological and environmental samples from EGS cases and controls.

自 2022 年 7 月 1 日起，Olivia Curry 开始了一个新的博士项目，在 Cathy Dwyer、Juliet Duncan 和 Gemma Pearson 的监督下开发评估马匹疼痛的行为方法。该学生项目将研究与马匹相关的原因、风险因素和诊断。草病（EGS），采用跨学科协作方法。生物和环境因素都将受到调查，学生有机会回顾所有可用的研究并使用多学科方法，找出知识差距并进行相关研究以阐明致病因素和风险因素。先前的研究已经研究了个体潜在的致病因素，但迄今为止在识别致病因素方面缺乏成功，这表明它可能是多因素的。该研究项目的主要内容将包括： - 开发一种包含 3D 肠道肠的相关且新颖的体外系统马培养物能够研究体外培养物与一些可能与马草病有关的主要候选致病因子的挑战后的早期宿主-病原体相互作用。 - 研究使用唾液作为马的非侵入性测试，以检测宿主对一系列候选抗原的免疫反应，这些候选抗原来自可能诱发马草病的潜在病原体。 - 该项目的样本将在近年来草病流行的选定地区进行纵向研究中收集。 - 建立国家生物库和数据库，包括制定调查问卷，与兽医、马主和研究人员合作，收集生物和来自 EGS 案例和对照的环境样本。