UCSD Mouse Research Facilities Improvement Program-Leichtag Bldg.

加州大学圣地亚哥分校小鼠研究设施改进计划-Leichtag Bldg.

• 批准号: 7082992
• 负责人: PHIL J RICHTER
• 金额: $ 66.3万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-05 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7082992
• 关键词: biomedical facility; density; health; housing; neoplasm /cancer

DESCRIPTION (provided by applicant): Amongst the four "barrier-type" facilities on the campus of the University of California, San Diego (UCSD), the Liechtag Biomedical Research vivarium includes18 rooms capable of supporting 108 racks and over 17,000 boxes of research mice. Funds are requested to purchase 24 high density mouse caging systems to expand the capacity of available housing space on the UCSD campus. At UCSD, diseaserelated genomic and translational research is a foremost priority. The proposed housing expansion will enable established and newly recruited faculty to conduct seminal studies in cancer biology, hematology, endocrinology, glycobiology, and toxicology. Discoveries in these areas will advance the prevention and safe treatment of important human diseases such cancer, Alzehiemer's and diabetes. In recent years it has become increasingly apparent that immunodeficient mouse strains and mice that are deficient in targeted genes require a stricter level of maintenance that precludes unwanted pathogen exposure. Such "barrier-type" facilities are critical to maintain the health of the animals and also to prevent spurious experimental results from occult infection and cytokine/chemokine release. Top Goals for the Animal Care and Use Program at UCSD are to maximize successful research, optimize animal well being, and ensure human health. We are currently focusing on "barrier-type" vivaria where we are upgrading housing systems for mice involved in PHS funded research. These upgraded housing systems will aid our efforts to maintain critically important animals healthy and free of unwanted mouse microbial agents and pathogens. Our specific aims are 1) to expand the capacity of "barrier-type" small animal research facilities, 2) to improve the health of mice by minimizing exposure to pathogens; and 3) to facilitate standardization of experimental results. To address these aims we wish to purchase with this grant 24 of the 108 high density individually ventilated mouse housing systems that are needed to support critical research animals sensitive to relatively minor changes in associated microflora. The University will provide the remaining 44 racks as funds become available.

描述（由申请人提供）： 在加州大学圣地亚哥分校 (UCSD) 校园内的四个“屏障型”设施中，Liechtag 生物医学研究动物园包括 18 个房间，可容纳 108 个架子和 17,000 多盒研究小鼠。需要资金购买 24 个高密度老鼠笼系统，以扩大 UCSD 校园可用住房空间的容量。在加州大学圣地亚哥分校，疾病相关的基因组和转化研究是首要任务。拟议的住房扩建将使现有和新招募的教师能够在癌症生物学、血液学、内分泌学、糖生物学和毒理学方面进行开创性的研究。这些领域的发现将促进癌症、阿尔茨海默病和糖尿病等重要人类疾病的预防和安全治疗。近年来，越来越明显的是，免疫缺陷小鼠品系和缺乏目标基因的小鼠需要更严格的维护水平，以防止不必要的病原体暴露。这种“屏障型”设施对于维持动物的健康以及防止隐匿感染和细胞因子/趋化因子释放造成的虚假实验结果至关重要。 加州大学圣地亚哥分校动物护理和使用项目的首要目标是最大限度地提高研究成功率、优化动物福祉并确保人类健康。我们目前专注于“屏障型”vivaria，我们正在升级参与 PHS 资助研究的小鼠的饲养系统。这些升级的饲养系统将有助于我们努力保持至关重要的动物健康，并且免受有害的小鼠微生物制剂和病原体的侵害。 我们的具体目标是1）扩大“屏障型”小动物研究设施的能力，2）通过尽量减少与病原体的接触来改善小鼠的健康； 3）促进实验结果的标准化。为了实现这些目标，我们希望利用这笔赠款购买 108 个高密度独立通风小鼠饲养系统中的 24 个，这些系统是支持对相关微生物区系相对较小变化敏感的关键研究动物所必需的。当资金到位时，大学将提供剩余的 44 个机架。