UCSD Rodent Phenotyping Core

加州大学圣地亚哥分校啮齿动物表型核心

• 批准号: 7853355
• 负责人: PHIL J RICHTER
• 金额: $ 45.95万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2011-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7853355
• 关键词: Animal Experimentation; Animals; Auditory; Boxing; California; Core Facility; Endocrine; Equipment; Funding; Growth; Hereditary Disease; Housing; Investigation; Learning; Memory; Metabolism; Mus; Nerve Degeneration; Nervous System Physiology; Phenotype; Population; Regimen; Research; Research Personnel; Resources; Rodent; System; Technical Expertise; Testing; Universities; Update; Work; base; programs

DESCRIPTION (provided by applicant): Continual growth in animal based research has led to a tripling of the UCSD mouse population over the past decade. The Rodent Phenotyping Core facility was recently established to provide phenotypic analysis for rodent-based investigations into a wide array of critical biomedical issues under study at the University of California, San Diego. Making key phenotyping equipment available for analysis of any of the over 45,000 boxes of rodents present on a daily basis was the basis for the establishment of this core resource. The resultant decreased need for costly duplication of space and resources is also a key component to the sustainability plan for the UCSD animal research program. Funding is requested to purchase nine key phenotyping systems encompassing metabolism, learning, memory, sensorimotor, auditory and neurologic functions that will offer new or updated capabilities for the studies ranging from neurodegenerative to endocrine to genetic disorders. Our specific aims are to 1) expand the centralized rodent phenotyping program making key testing available to all UCSD PHS funded researchers, and 2) modernize centralized rodent core phenotyping capabilities for UCSD PHS funded researchers. Because successful operating requirements for this core facility have been worked out including, space, technical expertise, associated housing for variable testing regimens, and online information handling system to support administration including transfer of animals from other facilities, the requested equipment will have an immediate impact on studies with the critical need for associated phenotypic analysis.

描述（由申请人提供）：基于动物的研究的持续增长导致 UCSD 小鼠数量在过去十年中增加了两倍。啮齿动物表型核心设施最近成立，旨在为加州大学圣地亚哥分校正在研究的一系列关键生物医学问题的啮齿动物调查提供表型分析。建立这一核心资源的基础是提供关键的表型分析设备来分析每天出现的 45,000 多箱啮齿动物。由此减少了对昂贵的空间和资源重复的需求，也是加州大学圣地亚哥分校动物研究项目可持续发展计划的一个关键组成部分。需要资金购买九个关键的表型分析系统，涵盖新陈代谢、学习、记忆、感觉运动、听觉和神经功能，这些系统将为从神经退行性疾病到内分泌到遗传性疾病的研究提供新的或更新的功能。我们的具体目标是 1) 扩大集中啮齿动物表型计划，为所有 UCSD PHS 资助的研究人员提供关键测试，2) 为 UCSD PHS 资助的研究人员实现集中啮齿动物核心表型分析能力的现代化。由于该核心设施的成功运营要求已经制定，包括空间、技术专长、用于可变测试方案的相关住房以及支持管理（包括从其他设施转移动物）的在线信息处理系统，因此所需的设备将产生直接影响迫切需要相关表型分析的研究。