Electrophysiological Correlates of Cognitive Processes

认知过程的电生理相关性

• 批准号: 6993560
• 负责人: WALTER P RITTER
• 金额: $ 20.83万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-05-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6993560
• 关键词: auditory cortex; auditory discrimination; auditory stimulus; auditory tracking; behavioral /social science research tag; brain electrical activity; clinical research; electroencephalography; evoked potentials; form /pattern perception; functional magnetic resonance imaging; human subject; illusions; neural information processing; neuroanatomy; sound frequency; sound perception; speech recognition; stimulus interval; videotape /videodisc; visual perception

DESCRIPTION (provided by applicant): The major focus of this research proposal is on the early processing of auditory information. The principal tool used in this endeavor is an event-related potential termed the mismatch negativity (MMN). Research with the MMN has uncovered a system located in auditory cortex that detects change in the acoustic environment on an automatic, pre-attentive basis. The proposal has four basic aims. One aim pertains to a pattern of MMN results obtained in the previous grant period suggesting that object formation occurs pre-attentively in the auditory system. One study will study examine the features that induce grouping of acoustic input. Another study will attempt to extend the finding to different acoustic features and will ascertain whether, in addition MMNs are elicited by switching from one object to another. A second aim is to ascertain whether MMNs are associated with illusory percepts. One study will examine illusory speech perceptions (the McGurk effect) and one study will examine illusory non-speech perceptions (the ventriloquist effect). The third aim is to establish neuronal generator sources for the MMN using fMRI. One fMRI study will attempt to localize the generator sources for MMNs associated with acoustic features (frequency and stimulus duration) and an abstract rule concerning acoustic features. Another fMRI study will attempt to localize the generator sources for MMNs associated with speech stimuli

描述（由申请人提供）：本研究建议的主要重点是听觉信息的早期处理。这项工作中使用的主要工具是事件相关的潜力，称为不匹配负性（MMN）。使用MMN的研究发现了一个位于听觉皮层中的系统，该系统以自动的，竞争的基础来检测声学环境的变化。该提案有四个基本目标。一个目的与在上一个赠款期间获得的MMN结果模式有关，该模式表明对象形成在听觉系统中发生。一项研究将研究诱导声学输入分组的特征。另一项研究将尝试将发现扩展到不同的声学特征，并确定是否通过将MMN从一个对象切换到另一个对象来引起MMN。第二个目的是确定MM​​N是否与虚幻的感知相关。一项研究将检查虚幻的语音感知（McGurk效应），一项研究将检查虚幻的非语音感知（腹膜效应）。第三个目的是使用fMRI建立MMN的神经元发生器源。一项功能磁共振成像的研究将尝试定位与声学特征（频率和刺激持续时间）相关的MMN的发电机来源，以及有关声学特征的抽象规则。另一项功能磁共振成像的研究将尝试将与语音刺激相关的MMN的发电机源定位