Age-Related Cognitive Loss in Mumbai, India

印度孟买与年龄相关的认知丧失

• 批准号: 6878582
• 负责人: DUSHYANT P PUROHIT
• 金额: $ 12.13万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6878582
• 关键词: India; aging; behavioral /social science research tag; clinical research; cognition disorders; culture; dementia; diagnosis design /evaluation; histopathology; human old age (65+); human subject; nervous system disorder diagnosis; neuropathology; neuropsychological tests; patient oriented research; psychometrics; racial /ethnic difference; tissue resource /registry; training

This R21 grant is designed to develop and facilitate collaborative research capabilites for studies on age-related cognitive loss at the TN Medical College/ Nair Hospital in Mumbai (Bombay), India, working in conjunction with the Mount Sinai School of Medicine Alzheimer's Disease Research Center (ADRC). This collaboration will involve experienced senior faculty at Mount Sinai who have long experience in research on Alzheimer's disease and other age-related neurodegenerative diseases. We propose to work with Dr. Charles Pinto, Professor of Psychiatry at the TN Medical College, one of the few Indian medical academic figures who has initiated an ongoing research program on age-related cognitive disorders. The targeted population for this collaborative study lives in Mumbai (Bombay), one of the largest urban populations in the world. The proposed research collaboration is of particular importance when one recognizes that India, the second most populous country in the developing world, has a very rapidly growing elderly population. We propose to modify existing screening instruments to be practical and culturally appropriate and use them to identify cases with impaired cognitive function. We will also assist in developing and implimenting culturally appropriate neuropsychological cognitive assessment tools and clinical diagnostic protocols for use in dementia research at the TN Medical College. Personnel at the TN Medical College will be trained in using these assessment instruments and generating data on cognitive function in a standardized fashion. Capacity for modern database operation with computerized data entry and storage will also be achieved. We will assist in the creation of the infrastructure and procedures needed to establish a Brain Bank facility in Mumbai. Using this facility, we will collect brains from elderly individuals coming to autopsy and evaluate them for the extent and distribution of Alzheimer's disease-related lesions. These specimens will be compared to age-matched specimens derived from New York to determine if there are differences in the tendency to develop such lesions in the two populations. The capabilities and preliminary data emerging from this R21 grant will be used to organize a proposal for more long-term studies of age-related cognitive loss in Mumbai utilizing the collaborative arrangements developed through the work of the current proposal. We anticipate that these studies will emphasize cliniconeuropathologic investigations in parallel with ongoing research at the Mount Sinai ADRC.

这项R21赠款旨在开发和促进合作研究毛细管，以研究印度孟买的TN医学院/ NAIR医院（印度孟买）与年龄相关的认知损失研究，并与西奈山医学院阿尔茨海默氏病研究中心（ADRC）合作。这项合作将涉及西奈山的经验丰富的高级教师，他们在阿尔茨海默氏病和其他与年龄有关的神经退行性疾病方面具有长期的研究经验。我们建议与TN医学院精神病学教授Charles Pinto博士合作，TN医学院是为数不多的印度医学学术人物之一，他启动了一项正在进行的有关年龄相关认知障碍的研究计划。目标 这项合作研究的人口居住在孟买（孟买），孟买是世界上最大的城市人口之一。当人们认识到，印度是发展中国家中第二大人口的国家，老年人口增长迅速时，提出的研究合作尤为重要。我们建议修改现有的筛选工具在实用和文化上适当，并使用它们来识别具有认知功能受损的病例。我们还将协助开发和强化文化适当的神经心理认知评估工具和临床诊断方案 TN医学院的痴呆症研究。 TN医学院的人员将接受使用这些评估工具的培训，并以标准化的方式生成有关认知功能的数据。还将实现现代数据库操作的能力，并可以实现计算机数据输入和存储的能力。我们将协助建立在孟买建立大脑银行设施所需的基础设施和程序。使用此设施，我们将从老年人的尸检中收集大脑，并根据阿尔茨海默氏病有关的病变的范围和分布进行评估。这些标本将与来自纽约的年龄匹配标本进行比较，以确定在两个种群中发生这种病变的趋势是否存在差异。出现的功能和初步数据 从这笔R21赠款中，将利用当前建议的工作开发的协作安排来组织一项对孟买与年龄相关的认知损失进行更长期研究的建议。我们预计，这些研究将与西奈山ADRC正在进行的研究同时强调临床病理学研究。