Age related Cognitive Loss in Mumbai, India

印度孟买与年龄相关的认知丧失

• 批准号: 7099992
• 负责人: DUSHYANT P PUROHIT
• 金额: $ 54.55万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7099992
• 关键词: Alzheimer' s disease; India; amyloid proteins; behavioral /social science research tag; biomedical facility; clinical research; cognition disorders; human old age (65+); human subject; longitudinal human study; memory disorders; neuritic plaques; neurofibrillary tangles; neuropathology; neuropsychological tests; postmortem; psychological aspect of aging; short term memory; technology /technique development; tissue resource /registry

DESCRIPTION (provided by applicant): This project is designed to further develop and facilitate collaborative research on age-related cognitive loss at the TN Medical College/Nair Hospital in Mumbai (Bombay) India, working in conjunction with the Mount Sinai Alzheimer's Disease Research Center (ADRC). This collaboration was initiated through support of an R21 Developmental Grant under the Brain Disorders in the Developing World: Research Across the Lifespan initiative. We now propose a more extensive RO1 grant to further develop the capabilities of our Indian colleagues to carry out research clinical evaluations and longitudinal assessments of cognitive function in the elderly as well as the preparation of postmortem brain specimens for neuropathologic diagnosis and brain banking. Epidemiologic studies of elderly Indian populations indicate that prevalence rates for Alzheimer's are dramatically lower than are seen in the developed nations. In this project, we will enroll, clinically assess, diagnose and longitudinally follow a cohort of 150 elderly individuals from Mumbai with mild to moderate cognitive impairment as well as a comparative group of 100 normal elderly controls. In addition, we will develop a facility for performing neuropathologic characterization and diagnostic evaluation of clinically evaluated subjects who come to autopsy during the course of the study. In doing this we will characterize the clinical features, natural history and neuropathologic correlates of cognitive loss among the urban elderly inhabitants of Mumbai. Finally, we will collect brain specimens from 120 elderly subjects from Mumbai who come to autopsy and are free of cognitive impairment (based on a postmortem Clinical Dementia Rating Score or CDR of 0). These brains will be compared with an age-matched series of brains obtained from the Mount Sinai Brain Bank collection (CDR=0) for the extent and distribution of neurofibrillary tangles and beta- amyloid deposits in the form of senile plaques, diffuse plaques and vascular amyloid accumulations. In this way, we will determine if, as our preliminary data suggest, in the course of normal aging the inhabitants of Mumbai show a decreased tendency to develop these cardinal neuropathologic features of Alzheimer's disease. In carrying out this project it is our overall objective to develop a center of expertise in research on age-related cognitive loss in Mumbai. The methodology we propose is patterned on that of the Clinical, Neuropathology, Database, and Education and Information Transfer Cores of the Mount Sinai ADRC, an established, effective and highly productive NIA-funded ADRC.

描述（由申请人提供）：该项目旨在进一步开发和促进与印度孟买TN医学院/NAIR医院有关年龄相关的认知损失的合作研究，并与西奈山阿尔茨海默氏病研究中心（ADRC）合作。这项合作是通过支持发展中国家脑部疾病下的R21发展补助金的支持来开始的：整个生命周期计划的研究。现在，我们提出了一项更广泛的RO1赠款，以进一步发展印度同事的能力，以进行研究临床评估和对老年人认知功能的纵向评估，以及为神经病理学诊断和脑库的验尸准备的准备。印度老年人口的流行病学研究表明，阿尔茨海默氏症的患病率远低于发达国家中所见。在这个项目中，我们将在孟买的150名老年人组成的队列中进行，临床评估，诊断和纵向介绍，具有轻度至中度的认知障碍，以及100个正常老年人对照组的比较组。此外，我们将开发一种用于对研究过程中临床评估的受试者进行神经病理学表征和诊断评估的设施。通过这样做，我们将表征孟买城市老年居民认知丧失的临床特征，自然史和神经病理学的相关性。最后，我们将从孟买的120名老年受试者中收集大脑标本，这些老年受试者尸检并没有认知障碍（基于死后临床痴呆评分评分或CDR为0）。这些大脑将与从西奈山脑库集合（CDR = 0）获得的年龄匹配的大脑进行比较，以以衰老的斑块，差异斑块和血管淀粉样蛋白淀粉样蛋白的堆积的形式进行神经原纤维缠结和β-淀粉样蛋白沉积物的分布。通过这种方式，我们将确定正如我们的初步数据所表明的那样，在正常衰老的过程中，孟买居民的居民表现出降低的趋势，即发展出阿尔茨海默氏病的这些基本神经病理特征。在进行该项目时，我们的总体目标是在孟买建立有关与年龄有关的认知损失研究专业知识的中心。我们提出的方法是根据Sinai Mount ADRC的临床，神经病理学，数据库以及教育和信息转移核心的图案图案，这是一个已建立，有效且高效的NIA资助的ADRC。