Clinical Models Workshop:Remin-Demin, Precavity, Caries

临床模型研讨会：Remin-Demin、预防性龋齿、龋齿

• 批准号: 6941850
• 负责人: George K Stookey
• 金额: $ 3.5万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941850
• 关键词: clinical trials; dental caries; dental development; preventive dentistry; travel; workshop

DESCRIPTION (provided by applicant): For at least two decades it has been recognized that more efficient models are needed for the conduct of clinical caries trials and this was emphasized at the NIDCR workshop held on May 6-7, 2004. Although there has been a significant amount of research focused on the development of more efficient models for these investigations there has been no agreement on acceptability of these clinical models for evaluating new caries-preventive measures. Thus, the overall goal of this conference is to develop a general consensus among the scientific community regarding the acceptability of new, more efficient models for clinical trials designed to assess the impact of caries-preventive measures on remineralization or demineralization, precavitation and caries. The Specific Aims of this workshop-conference will be to reach a consensus in the scientific community with respect to: (1) the identification of new, more efficient clinical models for use in conducting clinical evaluations of new caries preventive agents or measures; (2) the delineation of any special experimental conditions related to these models required for their scientific acceptance (test duration, treatment compliance, etc); and, (3) the initiation of the process for these clinical models to be accepted by various review agencies such as the ADA and the FDA. In essence, this proposed workshop-conference is designed to utilize scientific information generated in the past three years to build upon the progress made at the International Consensus Workshop on Caries Clinical Trials held in Loch Lomond, Scotland in January 2002. The conference will begin with a series of state-of-the-art presentations on different clinical methodologies to assess remin/demin, precavitation or cavitation stages of the disease. Then about 40 invited experts in cariology will work in small groups to address defined issues related to these methodologies. The meeting will be held on July 3-5, 2005 in the Downtown Marriott Hotel in Indianapolis, Indiana, immediately prior to the annual ORCA (European Organization for Caries Research) meeting.

描述（由申请人提供）：至少二十年来，人们已经认识到，进行临床龋齿试验的进行需要更有效的模型，并且在2004年5月6日至7日举行的NIDCR研讨会上强调了这一点。尽管有大量的研究集中在这些调查的开发上，但对这些临床量的可接受模型尚未达成共识，以衡量这些临床模型。因此，本次会议的总体目标是在科学界之间建立一般共识，涉及新的，更有效的模型在临床试验中的可接受性，旨在评估龋齿预防措施对回忆或脱矿化，休会和龋齿的影响。该研讨会会议的具体目的是在科学界达成共识：（1）鉴定新的，更有效的临床模型，用于对新龋齿进行临床评估，以进行新的龋齿预防剂或措施； （2）与这些模型相关的任何特殊实验条件的描述（测试持续时间，治疗依从性等）； （3）这些临床模型的启动被各种审查机构（例如ADA和FDA）接受。 In essence, this proposed workshop-conference is designed to utilize scientific information generated in the past three years to build upon the progress made at the International Consensus Workshop on Caries Clinical Trials held in Loch Lomond, Scotland in January 2002. The conference will begin with a series of state-of-the-art presentations on different clinical methodologies to assess remin/demin, precavitation or cavitation stages of the disease.然后，大约有40名受邀请的商品专家将在小组中工作，以解决与这些方法相关的定义问题。会议将于2005年7月3日至5日在印第安纳州印第安纳波利斯市中心的万豪酒店举行，直到年度ORCA（欧洲龋齿研究）会议之前。