IMPACT OF MALNUTRITION ON FLUORIDE PHARMACOLOGY

营养不良对氟化物药理学的影响

• 批准号: 6238490
• 负责人: George K Stookey
• 金额: $ 0.13万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1997-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6238490
• 关键词: China; Ecuador; air pollution; blood chemistry; dental caries; dental pharmacology; environmental toxicology; epidemiology; fluorine; fluorosis; genetic crossing over; human population study; human subject; hypocalcemia; malnutrition; nutrition related tag; pharmacokinetics; protein deficiency; public health; urinalysis; water supply

The cariostatic efficacy of fluoride present in communal water supplies is well-known and has resulted in the widespread use of fluoride in this manner, as well as in a variety of other delivery systems, for the prevention of dental caries. It is also known that the ingestion of excessive amounts of fluoride during the childhood period of tooth formation may result in the development of dental fluorosis. Additional reports have indicated that the presence of nutritional inadequacies serves to increase both the prevalence and severity of dental fluorosis and may also contribute to the development of skeletal fluorosis. However, virtually no information exists from human studies regarding the impact of nutritional inadequacies on any other possible pharmacologic or genotoxic effects of fluoride. In view of the widespread use of fluoride as well as the existence of nutritional inadequacies throughout the world, additional information is needed to permit and assure the safe public health use of fluoride for caries prevention. The long-term objective of this investigation is to provide necessary information to permit and assure the safe public health use of fluoride to prevent caries. The specific objectives of this investigation are to determine: (1) the relationship between chronic nutritional inadequacies and the prevalence/severity of dental and skeletal fluorosis associated with excessive fluoride ingestion; and (2) if nutritional inadequacies exacerbate any pharmacologic or genotoxic effects of fluoride in persons having chronic, excessive fluoride exposure. The investigation will involve population groups in The People's Republic of China and in Ecuador who have various combinations of nutritional inadequacies and fluoride exposure of varying degrees from either drinking water or ambient air. Collected data will include dental fluorosis and caries prevalence, nutritional status, skeletal fluorosis, fluoride content of urine and blood, and extensive chemical, electrolyte, and lymphocyte SCE assays of blood. The results of these studies will be useful in developing or refining current guidelines regarding the safe public health use of fluoride.

公共供水中存在的氟化物的cariostatic疗效是 众所周知，并导致广泛使用氟化物 方式以及在各种其他交付系统中 预防龋齿。 还知道摄入 牙齿的牙齿期间过多的氟化物 形成可能会导致牙齿氟中毒的发展。 额外的 报告表明，营养不足的存在有效 增加牙齿氟中毒的患病率和严重程度，可能 也有助于骨骼氟中毒的发展。 然而， 几乎没有人类研究的信息 任何其他可能的药理学或遗传毒性的营养不足 氟化物的影响。 鉴于广泛使用氟化物以及 全世界存在营养不足的存在，额外 需要信息以允许和确保安全的公共卫生使用 预防龋齿的氟化物。 这项调查的长期目标是提供必要的 允许和确保氟化物安全使用的信息 防止龋齿。 这项调查的具体目标是 确定：（1）长期营养不足之间的关系 以及牙齿和骨骼氟中毒相关的患病率/严重程度 过多的氟化物摄入； （2）如果营养不足 加剧氟化物对人的任何药理或遗传毒性作用 慢性氟化物暴露过多。 调查将 参与中华人民共和国和厄瓜多尔的人口群体 他们具有各种营养不足和氟化物的组合 从饮用水或环境空气中接触不同程度的程度。 收集的数据将包括牙齿氟中毒和龋齿患病率， 营养状况，骨骼氟中毒，尿液的氟化物含量和 血液和广泛的化学，电解质和淋巴细胞SCE测定法 血。 这些研究的结果将在开发或 完善有关安全公共卫生使用的当前准则 氟化物。