Development of QLF Handpiece for Early Caries Detection

开发用于早期龋齿检测的 QLF 手机

• 批准号: 7127609
• 负责人: George K Stookey
• 金额: $ 36.41万
• 依托单位: THERAMETRIC TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-08 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127609
• 关键词: adolescence (12-20); bioengineering /biomedical engineering; clinical biomedical equipment; clinical research; computer program /software; computer system design /evaluation; data collection methodology /evaluation; dental caries; dental disorder diagnosis; dental visualization; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder proneness /risk; early diagnosis; ergonomics; fluorescence; human subject; image enhancement; middle childhood (6-11); oral health; orthodontics; patient oriented research; portable biomedical equipment; tooth enamel

DESCRIPTION (provided by applicant): During the past 40 years there has been a remarkable decline in the prevalence of dental caries due to the widespread use of fluoride in public health programs, such as communal water fluoridation, dental practice and in oral hygiene products. In spite of this, dental caries continues to be the most prevalent dental disease. It is known that the traditional visual-tactile clinical caries examination procedure cannot detect lesions until they advance to the stage where they are difficult to reverse with fluorides and other measures. The understanding of the caries process has progressed far beyond the point of restricting the evidence for dental caries at the E2 (caries in enamel only) or D3 (caries in enamel and dentin) levels of cavitations. Recording lesions only at the cavitation level is no longer acceptable (ICCCT, 2002). Quantitative Light Fluorescence (QLF) is a technology that has been shown to detect and quantify the progress of lesions at an early stage (pre-cavitation). This technology will allow dental practitioners to: (a) identify early enamel demineralization reflecting caries risk prior to cavitation; (b) implement appropriate interventions to reverse the disease process at an earlier stage with more efficient outcomes; and (c) monitor the success or failure of the applied intervention measures. The overall goal of this program is to develop a QLF research system for use in clinical dental practice. The Phase I program successfully overcame the limitations of a research hand-piece to permit routine clinical use. The Phase 2 program seeks to further refine the instrument hardware and user software to make the technique practical within clinical practice. The specific aims of this application are to: (1) refine the instrument to make it more ergonomic and facilitate practical infection control procedures; (2) verify the ability of the redesigned instrument to detect early caries and monitor changes in a laboratory; (3) develop user-friendly computer software interfaces that are compatible with the existing software for use by dental professionals; (4) develop appropriate training materials; (5) verify efficacy of the system through a clinical investigation. The results of this research should improve dental health of the general population by identifying dental patients at greater risk of developing dental caries and result in the implementation of interventions to reverse the process and reduce or prevent the need for restorations.

描述（由申请人提供）：在过去的40年中，由于在公共卫生计划中广泛使用氟化物，例如公共水氟化，牙科实践和口腔卫生产品，龋齿的患病率显着下降。尽管如此，龋齿仍然是最普遍的牙齿疾病。众所周知，传统的视觉症临床龋齿检查程序无法检测到病变，直到它们前进到难以通过氟化物和其他措施逆转的阶段。对龋齿过程的理解已经远远超出了限制E2（仅在搪瓷中的龋齿）或D3（搪瓷和牙本质中的龋齿）水平的龋齿证据的地步。仅在空化水平上记录病变是不再可接受的（ICCCT，2002）。定量光荧光（QLF）是一项已显示可检测和量化早期病变进度的技术（预售）。该技术将使牙科医生能够：（a）确定早期的搪瓷脱矿化，反映了龋齿的风险； （b）实施适当的干预措施，以更有效的结果在早期阶段扭转疾病过程； （c）监视应用干预措施的成功或失败。该计划的总体目标是开发QLF研究系统，用于临床牙科实践。 I期计划成功地克服了研究手件的局限性，以允许常规的临床使用。第二阶段计划旨在进一步完善仪器硬件和用户软件，以在临床实践中实用该技术。本应用的具体目的是：（1）完善该工具以使其更符合人体工程学并促进实际感染控制程序； （2）验证重新设计的仪器检测早期龋齿和监测实验室变化的能力； （3）开发与现有软件兼容的用户友好的计算机软件接口，供牙科专业人员使用； （4）开发适当的培训材料； （5）通过临床研究验证系统的功效。这项研究的结果应通过识别出更大风险出现龋齿风险的牙科患者来改善普通人群的牙齿健康，并导致实施干预措施以扭转过程，减少或防止需要修复。